In this work, molecular modeling and docking studies of antimicrobial heterocyclic compounds were carried out using Auto Dock. Docking studies were carried out for Benzodiazole derivatives to study their affinity to Cell wall anchored (CWA) protein of Staphylococcus aureus. The d...
Open access
Research Article10.9734/jpri/2020/v32i2930890
Meconium stained amniotic fluid (MSAF) is a commonly studied topic in neonatal outcomes. Meconium was commonly thought a precursor to eventual or active fetal death, although, some scholars do not consider this to be connected with foetal hypoxia, fetal acidosis, or trauma. Purpo...
Open access
Research Article10.9734/jpri/2020/v32i2930891
Introduction: Studies have shown the association between subclinical hypothyroidism and type 2 diabetes. However, the common complications of type 2 diabetes, such as diabetic nephropathy and albuminuria with subclinical hypothyroidism, are not fully clear yet. This study thus ai...
Open access
Research Article10.9734/jpri/2020/v32i2930885
Aim: The study aimed to analyze the effect of Sitagliptin with Glimepiride during the treatment to improve pancreatic beta-cells in T2DM patients. Beta cells are type of cell found in pancreatic islet and also synthesize, secrete the insulin and amylin. Sitagliptin is found to be...
Open access
Research Article10.9734/jpri/2020/v32i2930887
The cancer is the world's most silent and life-threatening diseases, which may arise in most common people without any indication at any age and result in uncontrolled growth and metastasis. In the current manuscript, we targeted the discovery of novel carbonic anhydrase IX inhib...
Open access
Research Article10.9734/jpri/2020/v32i2930886
Background: Our previous study of the lipid peroxidation and antioxidant defense system (LPO-AOS) state in women with chronic viral hepatitis (CVH) showed the content of fat-soluble vitamin alpha tocopherol significant reduction. Reproductive health of women with CVH needs specia...
Open access
Research Article10.9734/jpri/2020/v32i2930884
Background and Objective: Polo like kinase-1 (PLK-1) enzyme belongs to serine/threonine protein kinase family that is regarded as a principle mitotic controller of G2-M phase transition. The antimitotic therapies are a cornerstone for the treatment of metastatic as well as benign...
Open access
Research Article10.9734/jpri/2020/v32i2930880
Ali Bahari, Mohammad Hashemi, Gholam Reza Bahari, Tahereh Fakharian, Sina Gerayli, Abbas Esmail Zadeh, Hamid Reza Sima, Hooman Mosannan Mozaffari, Ali Reza Bakhshipour & Zohreh Bari·Journal of Pharmaceutical Research International·2020
Background: Selecting patients for new direct acting antiviral treatment of HCV has prompted a conflicting matter worldwide because of its high cost and limited availability. Genotyping of IL28B polymorphisms will aid clinical decision making for identifying priorities of urgent...
Open access
Research Article10.9734/jpri/2020/v32i2930881
Objective: To assess the early risk factors and outcomes of the patients presented with acute renal issues, at tertiary care Hospital. Methodology: This descriptive study was conducted at gynaecology and obstetrics department of Liaquat University of medical and health Sciences....
Open access
Research Article10.9734/jpri/2020/v32i2930882
Aims: Biotic stress given by Aspergillus niger enhances trans-resveratrol production in Arachis hypogaea plant. This plant extract increases sir2 gene expression and Replicative Life Span in Saccharomyces cerevisiae. Design of Study: Peanut plant was grown in aseptic environmen...
Open access
Research Article10.9734/jpri/2020/v32i2930883