Genome-wide association studies (GWAS) have identified variants associated with type 2 diabetes (T2D), but less than five percent of the genetic variance associated with T2D is accounted for in GWAS studies performed using T2D as endpoint. These findings suggest relevance of asse...
Open access
Research Article10.9734/BJMMR/2014/5155
Denosumab is a potent novel antiresorptive agent for treatment of osteoporosis with unique mechanism of action . It is a fully human monoclonal antibody to the receptor activator of nuclear factor-κB ligand (RANKL) that blocks its binding to RANK, inhibiting the development and a...
Open access
Research Article10.9734/BJMMR/2014/6300
The majority of penile cancers develop from squamous cells within the skin resulting in a non-melanoma form of skin cancer, squamous cell carcinoma. Squamous cell carcinomas can develop anywhere on the penis, most appear on the foreskin in men who have not been circumcised or on...
Open access
Research Article10.9734/BJMMR/2014/4677
Aims: The aim of this study was to investigate of the roles of CD5+ and CD19+ on lymphocytes, CD5+ on B lymphocytes, CD41a+ on platelets and CD55+ and CD59+ on erythrocytes in platelet destruction; and evaluate them according to the patient response status to steroid therapy and...
Open access
Research Article10.9734/BJMMR/2014/5325
Posttraumatic stress disorder is a type of anxiety disorder that manifests after exposure to a traumatic event that was perceived as life threatening. Individuals with posttraumatic stress disorder have a deficiency in the extinction of fear memory. Moreover, environmental cues s...
Open access
Research Article10.9734/BJMMR/2014/5219
Aims: The objective of this research is to extract the aorta and to measure its diameter for preoperative planning of heart surgeries such as Endo Vascular Aortic Repair (EVAR) or Aortic Valvular Replacement (AVR). Study Design: Experimental Study. Place and Duration of Study: De...
Open access
Research Article10.9734/BJMMR/2014/5050
Aims: Neurotransmitter overflow into the extracellular space and activation of nitric oxide synthase were implicated in neuronal death after cerebral ischemia. A small temperature reduction induced after the insult crucially mitigated the neuronal death. To elucidate the mechanis...
Open access
Research Article10.9734/BJMMR/2014/3399
Aims: To investigate women’s perceptions of miscarriage and its complications. Study Design: A qualitative design was used with data collected through semi-structured interviews. Place and Duration of Study: Gynaecology ward of the Queen Elizabeth Central Hospital, Blantyre, Mala...
Open access
Research Article10.9734/BJMMR/2014/6402
Aims: Several scoring systems have been developed for diagnosis of appendicitis. This study aims to systematically explore how those scores were derived and validated, and to compare their performance. Study Design: Systematic review. Place and Duration of Study: We searched Medl...
Open access
Research Article10.9734/BJMMR/2014/5255
Background: Garcinia kola (bitter kola) is one of the most common masticatories in Nigeria having social and ethnomedicinal applications. G. kola seeds are believed to contain caffeine, one of the major constituent of coffee which is also believed to improve memory. Aim: This stu...
Open access
Research Article10.9734/BJMMR/2014/5352