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All published articles 7450

Parthenolide Induces Apoptosis and Cell Cycle Arrest by the Suppression of miR-375 Through Nucleolin in Prostate Cancer

Rajesh Kannan Moorthy, Sridharan Jayamohan, Mahesh Kumar Kannan & Antony Joseph Velanganni Arockiam · Journal of Pharmaceutical Research International · 2021

Aims: To investigate the effect of parthenolide on nucleolin in controlling the expression of miR-375 that induces apoptosis and cell cycle arrest in prostate cancer. Study Design: This study is an experimental study. Methodology: The cytotoxicity effect of parthenolide was teste...

Open access Research Article 10.9734/jpri/2021/v33i45A32736

Knowledge of Healthcare Professionals Regarding the Primary Management of Anaphylaxis in Madinah, Saudi Arabia

Nasser S. AlHaddad, Abdul Rahman A. Alshaeri, Athar A. Faidh, Yaser M. Alahmadi, Hossein M. Elbadawy & Ahmed J. Aldhafiri · Journal of Pharmaceutical Research International · 2021

Aim: To assess the knowledge, attitude and practice of healthcare professionals regarding the anaphylaxis in Medina, Saudi Arabia. Settings and Design: This was a population-based epidemiological study using a survey composed of 20 questions about the causes, symptoms, and treatm...

Open access Research Article 10.9734/jpri/2021/v33i45A32737

A Comparative Study of Active Management of the Third Stage of Labor IV Methergine and IM Oxytocin

K. Sharmila · Journal of Pharmaceutical Research International · 2021

Postpartum haemorrhage (PPH) has been more common over the last three decades, accounting for 11% of all pregnancy-related deaths in the United States. In the third stage of labour, risk classification and active management are crucial preventative techniques. To avoid negative e...

Open access Research Article 10.9734/jpri/2021/v33i45A32743

Multielemental Screening and Analytical Method Validation for Determination of Elemental Impurity in Sucroferric Oxyhydroxide by Using (ICP-MS)

Vikas Kumar Singh, Santosh Kumar Verma & Sudhanshu Ranjan Swain · Journal of Pharmaceutical Research International · 2021

A highly selective, specific, precise sensitive and reliable ICPMS method has been developed and validated by using ICP-MS for the determination of multielement in Sucroferric oxyhydroxide. The described ICP-MS method provides specific detection and quantification of minor and tr...

Open access Research Article 10.9734/jpri/2021/v33i45A32744

The Histopathology of Carcinoma Breast with Special Reference to p53 Marker

Meera Balakrishnan · Journal of Pharmaceutical Research International · 2021

Introduction: Breast cancer is one of the most common cancers among women in the world. The high incidence of breast carcinoma in women has inspired a thorough investigation of potentially modifiable risk variables (clinical parameters, morphological type, and biochemical indicat...

Open access Research Article 10.9734/jpri/2021/v33i45A32745

The Role of Orthodontic Treatment and Prosthetics during the Recovery Period after Surgical Treatment

Timerlan Aslambekovich Kadiyev, Muslim Kazbekovich Aigumov, Tatyana Timokhina, Kirill Dmitrievich Baranov, Marina Mikhailovna Krekova & Vitaly V. Goncharov · Journal of Pharmaceutical Research International · 2021

The present paper considers the role of orthodontic treatment and prosthetics in the recovery period after surgical treatment of an injury to the maxillofacial area. Analyzing the sources within the framework of the research topic, the author cconcludes tthat surgical treatment o...

Open access Research Article 10.9734/jpri/2021/v33i45A32728

Delirium in a Male Patient Following Recovery from Mild COVID-19 Infection

Yasir I. Alsenaidi, Khalid F. Alsadhan, Mohammed W. Alwhibi, Hessah I. Almezail & Abdullah A. Alrasheed · Journal of Pharmaceutical Research International · 2021

COVID-19 has had a worldwide impact that is unprecedented and catastrophic. Infection with COVID-19 can cause various neuropsychiatric complications, including delirium, which is commonly reported with the acute phase of illness with COVID-19 infection. However, delirium after co...

Open access Research Article 10.9734/jpri/2021/v33i45A32730

Lag Screws in Maxillofacial Trauma- A Review

Subhashini Ramasubbu · Journal of Pharmaceutical Research International · 2021

The etiology of mandibular fractures includes mainly assaults and road traffic automobile accidents. Additionally, fall and sports injuries are the foremost common causes for mandibular fractures. Mandibular fractures outnumbered zygomatic and maxillary fractures by a ratio of 6:...

Open access Research Article 10.9734/jpri/2021/v33i45A32721

Skanda (Bala Graha) and Cerebral Palsy – A Review

Pinakumari I. Patel, Swapnil C. Raskar, Aboli Patil, Sudhir Pani & Vishal Prajapati · Journal of Pharmaceutical Research International · 2021

Among the Ashtanga Ayurveda, Kaumarbhritya focuses on child care in particular. Graharogais the most neglected portion due to excess mythological explanation, difficulty in clinical understanding, diagnosis, severity, complication, and treatment is entirely different from the rou...

Open access Research Article 10.9734/jpri/2021/v33i45A32724

Dermatophytosis in a Suburban Hospital-A Study on Distribution and Clinical Types According to Age and Sex

Aishwarya Shankar & Jayakar Thomas · Journal of Pharmaceutical Research International · 2021

Aim and Objectives: Dermatophytosis is a fungal infection of the outermost layer of skin and its appendages such as hair, nails and scalp. The present study was undertaken with a view to find out the clinical pattern of dermatophytic infections in our hospital. Materials and Meth...

Open access Research Article 10.9734/jpri/2021/v33i45A32722

Formulation and Evaluation of Vaginal Bioadhesive Drug Delivery System of Acyclovir

Bhaskar Mohite, Rakesh Patel & Nandu Kayande · Journal of Pharmaceutical Research International · 2021

Acyclovir is an anti-viral, which has been used in the treatment of vaginal disorder. Acyclovir is almost completely absorbed after oral administration but has low bioavailability of about 10-15% because of first pass metabolism. As first pass metabolism removes approximately 85-...

Open access Research Article 10.9734/jpri/2021/v33i45A32723

Preclinical Screening of Antidepressant Activity of Formulated Sertraline Hydrochloride-Loaded Solid Lipid Nanoparticles in Rats

Sachin R. Hangargekar, Pradeep K. Mohanty & Janki Prasad Rai · Journal of Pharmaceutical Research International · 2021

Objective: The main goal of our study was to investigate the antidepressant activity of Formulated Sertraline hydrochloride-loaded Solid Lipid Nanoparticles (SLNPs) by using a rat forced swimming test (FST) and tail suspension test (TST). Materials and Methods: Animals were divid...

Open access Research Article 10.9734/jpri/2021/v33i45A32725

Stability-indicating RP-UPLC Method for Determination of Vildagliptin in Drug Substance and Its Tablet Dosage Form

Kalyani Peluri & S. Rajasekaran · Journal of Pharmaceutical Research International · 2021

Aim: The foremost purpose of this research work is to diminish the analysis time and to establish cost effective method for estimation of Vildagliptin by RP-UPLC. Study Design: UPLC based Quantification studies. Place and Duration of Study: Department of Pharmacy, Bhagwant Univer...

Open access Research Article 10.9734/jpri/2021/v33i45A32726

Normal Reference Range for Serum TSH, Free T4, Total T4, and Total T3 on Roche® Platforms in Basrah, Iraq

Nassar Taha Alibrahim, Samih Abed Odhaib, Ali Hussain Alhamza, Ammar Mohammed Saeed Almomin, Ibrahim Abbood Zaboon, Rudha Naser Hussein, Muayad Baheer Kadhim, Adel Gassab Mohammed, Dheyaa Kadhim Al-Waeli, Hussein Ali Nwayyir, Haider Ayad Alidrisi, Ibrahim Hani Hussein, Mahmood Thamer Altemimi, Husam Jihad Imran & Abbas Ali Mansour · Journal of Pharmaceutical Research International · 2021

Background: Thyroid function tests are mandatory in clinical practice because symptoms and signs are not reliable to discriminate between various types of thyroid disease. Aim: The aim of this study was to determine assay-specific reference range for serum free T4, total T4, tota...

Open access Research Article 10.9734/jpri/2021/v33i45A32727

A Comparative Study on Isolation and Characterization of Lecithin from Gallus gallus and Gallus Domesticus Using Analytical Methods

S. F. Choragudi, N. Sibin, M. Keerthi Padma Sree, Gulam Saleem, K. Prashanth Babu & C. H. Arun · Journal of Pharmaceutical Research International · 2021

The present study mainly focuses on the extraction and purification of lecithin from both Gallus gallus and Gallus gallus domesticus. The comparative study shows a great significance in the amount and quality of lecithin extracted from both the sources. The egg lecithin was stand...

Open access Research Article 10.9734/jpri/2021/v33i45A32729