Umida Khamidova, Ekaterina Terenteva, Mukaddas Umarova, Jaloliddin Abdurakhmanov, Sabirdjan Sasmakov, Artyom Makhnyov, Valentina Vinogradova, Abdusalom Saidov, Zaynat Khashimova & Shakhnoz Azimova·Journal of Pharmaceutical Research International·2021
A row of 1-alkyne (C6-C17) derivatives against tetrahydroisoquinoline have been synthesized. 1-alkyne (C6-C17) derivatives cytotoxicity against three lines of cancer cells and two lines of normal cells was studied. It was found that 1-tridecyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoq...
Open access
Research Article10.9734/jpri/2021/v33i46B32938
Background: Long term intake of high amount of fluoride leads to fluorosis causing metabolic, functional and structural damages affecting many tissues and organs including dental and skeletal manifestations. The liver is the most susceptible organ to fluoride toxicity because of...
Open access
Research Article10.9734/jpri/2021/v33i46B32939
Aims: The aim of present study was to develop a stomach specific formulation of Imatinibmesylate to increase the fraction of drug absorbed in stomach. Study Design: Development and Optimization of Microspheres for site specific delivery.. Place and Duration of Study: The study wa...
Open access
Research Article10.9734/jpri/2021/v33i46B32941
Infertility is a serious issue disturbing reproductive ages in all society now and calling for solution for continuity. Infertility were induced on groups of animals with separate sexes; M, M1, M2 and M3; F, F1, F2 andF3 with daily subcutaneous administration of 20 mg/kg body wei...
Open access
Research Article10.9734/jpri/2021/v33i46B32942
Farkhod Eshboev, Elvira Yusupova, Galina Piyakina, Sabirdjan Sasmakov, Jaloliddin Abdurakhmanov, Shuhrat Khasanоv, Oybek Ashirov, Sherali Kuziev, Durdona Toshpulatova & Shakhnoz Azimova·Journal of Pharmaceutical Research International·2021
Drug addiction is one of the biggest problems of medicine because diagnosis and treatment of drug addiction are difficult compared with some other socially significant diseases. In this study, synthesis and evaluation of four carrier protein-morphine conjugates were experimented....
Open access
Research Article10.9734/jpri/2021/v33i46B32943
Aim: The current research paper describes the “Regulatory procedure of post approval changes and comparative regulatory requirement of EU and USA regulatory regions”. Study Design: The present study is a type of Retrospective analysis of Regulatory requirements and the reviewed d...
Open access
Research Article10.9734/jpri/2021/v33i46B32944
Objective: To evaluate the prescribing pattern of empagliflozin with respect to other concomitant prescribed drugs in a diabetic patient. Methods: The present research study was conducted in Dhaka from May 2021 to July 2021 at National Healthcare Network (NHN), Dhaka (Jurain, Utt...
Open access
Research Article10.9734/jpri/2021/v33i46B32945
The separation of the follicle from around the crown of an unerupted tooth causes formation of dentigerous cyst. It may undergo metaplasia in several cases. In this case a 30 year old female patient reported with a history of dentigerous cyst with respect to impacted 48. The swel...
Open access
Research Article10.9734/jpri/2021/v33i46B32919
The stress of weaning piglets negatively affects all factors of the body. First of all, this affects the violation of nutrition and a decrease in the activity of the immune system. The use of probiotics allows to reduce the negative consequences caused by weaning from a sow. The...
Open access
Research Article10.9734/jpri/2021/v33i46B32923
With the rapid spread of severe acute respiratory syndrome SARS-CoV2, the incidence of the disease is increasing each day with a higher infectivity rate and unpredictable morbidity and mortality. The second wave in India has higher morbidity and mortality compared to the previous...
Open access
Research Article10.9734/jpri/2021/v33i46B32926
An unusual rise in blood glucose linked with the use of glucocorticoids in a patient with or without a prior history of diabetes mellitus is referred to as steroid-induced diabetes mellitus. The term steroid refers to a group of chemicals that have varied physiological effects. H...
Open access
Research Article10.9734/jpri/2021/v33i46B32924
Stenosiphonium russellianum Nees. is rarely known species belongs to the family Acanthaceae and it is a shrub, found above 500m on slopes of mountain. It was traditionally used for wound healing in and as blood purifier. The current study designed to provide the requisite pharmac...
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Research Article10.9734/jpri/2021/v33i46B32920
Objectives: Acute tonsillitis is an inflammatory process of tonsil tissue and is usually infectious. Acute tonsillitis starts suddenly and usually disappears within one to two weeks. This study aims to isolate bacteria from patients with infectious tonsillitis and determine the a...
Open access
Research Article10.9734/jpri/2021/v33i46B32921
Background: The current study assesses the incidences and grades of phlebitis among patients with IV cannula to determine the association of grades of phlebitis. The purpose of the study was to study the feasibility of Routine replacement versus Clinically indicated replacement o...
Open access
Research Article10.9734/jpri/2021/v33i46B32922
Background: To overcome drug resistance to current antimalarial drugs, we propose the synthesis and in vitro evaluation of the antiplasmodial activity of a series of 5-chlorobenzimidazolyl-chalcones against chloroquino sensitive (CQ-S) and chloroquino resistant (CQ-R) strains of...
Open access
Research Article10.9734/jpri/2021/v33i46B32925