The concept of Domination in graphs has application to the study of DNA structures. For investigating the chemical and physical properties, several topological indices used are Wiener index, Randic index, Zagreb index, Kier & Hall index that depends on vertex degree and dista...
Open access
Research Article10.9734/jpri/2021/v33i47A33045
Aims: The aim of the present study was to develop and optimize a Stealth Liposomal Drug Delivery System of microtubule inhibitor using Box–Behnken Design and Desirability function. Study Design: Development and Optimization of Stealth Liposomes. Place and Duration of Study: The s...
Open access
Research Article10.9734/jpri/2021/v33i47A33046
Introduction: Liver Cancer is aggressive cancer and patients are mostly screened and diagnosed when they become symptomatic at advanced. Disease severity, depression, fatigue, joint pain, and poor appetite have been reported as strong determinants of quality of life (QoL) among l...
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Research Article10.9734/jpri/2021/v33i47A33047
Human Gasdermin A (GSDMA), a member of gasdermin gene family, is mainly expressed in skin and stomach. Mutations in its mouse counterpart Gsdma3, were found to cause skin diseases characterized by hair loss/ alopecia. As human and mice genes share 75% sequence similarity, present...
Open access
Research Article10.9734/jpri/2021/v33i47A33048
Ibrahim Dighriri, Ahmed Mobarki, Naif Althomali, Khalid Alqurashi, Othman Daghriri, Bashaer Bin Howimel, Izdihar Alahmad, Rawan Alsaadi, Manar Alsufyani, Manar Balobade, Reem Altemani, Bayader Alatawi, Wejdan Sharoufna, Taif Almuntashiri & Sultan Almushawwah·Journal of Pharmaceutical Research International·2021
Introduction: Metronidazole has been prescribed to treat infections for over a century and continues to be helpful in the therapy of amoebiasis, trichomoniasis, and giardiasis. Metronidazole is a cost-effective medication because of its low price, few adverse effects, and favorab...
Open access
Research Article10.9734/jpri/2021/v33i47A33049
Cardiac glycosides, including digitalis and digoxin, have long-standing use in clinical practice. Digoxin has a half-life that varies from 36 to 48 hours, which may increase in cases of renal failure. Approximately 1% of Congestive Heart Failure patients treated with digoxin deve...
Open access
Research Article10.9734/jpri/2021/v33i47A33025
COVID-19 pandemic has affected the world in all its dimensions. With herd immunity being a distant and non-practical possibility, vaccination remains most tractable approach to reduce morbidity and mortality. Several early phase clinical trials have proved the immunogenicity of v...
Open access
Research Article10.9734/jpri/2021/v33i47A33035
Bacterial vaginosis is condition in which abnormal vaginal discharge can cause. Due to this sexually transmitted diseases are causing in the women. In the bacterial vaginosis there is an imbalance in the vaginal acidity the pH becomes more than 5 the bacteria becomes overgrowth a...
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Research Article10.9734/jpri/2021/v33i47A33027
Background of the Study: First aid involving simple but life-preserving techniques which can be performed with minimum facilities and without having any medical experience. Snowballing in the number of educated individuals, comprising the school pupils who can play a vital role i...
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Research Article10.9734/jpri/2021/v33i47A33028
Heba Alkhatabi, Heyam Abdulqayoom, Raed Alserihi, Raed Felimban, Aisha Elaimi, Zinab Allala, Afaf Magboli, Salem Bahashwan, Hashem Alsalmi, Abdulelah Shihah, Adel Abuzenadah & Elrashed B. Yasin·Journal of Pharmaceutical Research International·2021
Background: The JAK2 V617F mutation’s discovery has largely facilitated the comprehension of the myeloproliferative neoplasms’(MPNs) pathogenesis. In recent times, calreticulin (CALR) mutations have been detected in patients with JAK2V617F negative primary myelofibrosis (PMF), an...
Open access
Research Article10.9734/jpri/2021/v33i47A33029
Aims: To assess the levels of perceived stress among college students in Saudi Arabia after changing the learning protocols because of covid-19 pandemic. Study Design: This was a cross-sectional study. Place and Duration of Study: The study was conducted in Saudi Arabia, from May...
Open access
Research Article10.9734/jpri/2021/v33i47A33030
The pharmaceutical industry of India is one of the most rapidly expanding research-based industries of Indian manufacturing. This paper attempts to examine the trends in partial and total factor productivity (TFP) growth of India’s pharmaceutical industry using industry-level tim...
Open access
Research Article10.9734/jpri/2021/v33i47A33031
Objective: To determine the diagnostic accuracy of doppler ultrasound in the diagnosis of testicular carcinoma, by taking histopathology as gold standard. Methods: This cross-sectional study was carried out at Radiology department of Liaquat University of Medical and health Scien...
Open access
Research Article10.9734/jpri/2021/v33i47A33032
The Janus kinase signal transducer and activator of transcription (JAK / STAT) signalling, which is crucial in Philadelphia-negative myeloproliferative neoplasms’ (MPNs), is negatively regulated by molecules such as SOCS, CISH, and SHP1. SOCS2 methylation has been studied in MPN...
Open access
Research Article10.9734/jpri/2021/v33i47A33033
Objective: To analyze the harmful effect of COX-2 inhibitor on proximal convoluted tubular diameter of kidney, amendment by lycopene. Research Design: Experimental Research. Abode of Research: Animal House, JPMC, Karachi. Materials and Methods: 90-120 days old, forty healthy adu...
Open access
Research Article10.9734/jpri/2021/v33i47A33034