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All published articles 7450

Targeting Omp-A Protein of Acinetobacter Baumannii with the Bio-Active Compounds from Azadirachta Indica - an in-silico Approach

R. Nandita, A. S. Smiline Girija, P. Sankar Ganesh & J. Vijayashree Priyadharsini · Journal of Pharmaceutical Research International · 2021

Background: Acinetobacter baumannii is a gram negative bacterium which is typically short, round, coccobacillus and was named after the bacteriologist Paul Baumann. It is an emerging dental pathogen since it acquires  drug resistance and expression of several virulence genes. It...

Open access Research Article 10.9734/jpri/2021/v33i48B33290

Assessment of Risk Factors and Prevalence of under Nutrition Using Composite Index of Anthropometric Failure (CIAF) among under 5 Children in a Tertiary Care Center

M. Devika & N. Kishore · Journal of Pharmaceutical Research International · 2021

Background: Under nutrition is a major health problem in the developing countries especially India. It has a significant impact to child morbidity and mortality. Objective: To assess the risk factor and prevalence of under nutrition among children under 5 years of age, using conv...

Open access Research Article 10.9734/jpri/2021/v33i48B33293

Prevalence, Clinical Profile and Outcome of Patients Presenting with Stroke

N. Akshaya Thrinetrapriya & M. Jagadeesan · Journal of Pharmaceutical Research International · 2021

BACKGROUND: Stroke is a clinical condition that has a greatly increasing prevalence in the recent years owing to our ‘modern’ sedentary lifestyle. The aim of this study is to assess the prevalence, risk factors, clinical presentation and outcome of patients presenting with stroke...

Open access Research Article 10.9734/jpri/2021/v33i48B33273

Role of Letrozole in Management of Female Infertility; Review Article

Maha Fouad Messawa, Salma Yousef Omar & Reem Ahmed Babagi · Journal of Pharmaceutical Research International · 2021

Background: Letrozole is a highly steroidal and selective oral aromatase inhibitor (AI). Serval studies shows that Co-treatment with letrozole significantly reduced gonadotropin consumption and the incidence of Ovarian Hyperstimulation Syndrome in normal/high responders, with pre...

Open access Research Article 10.9734/jpri/2021/v33i48A33249

Incidence of Autonomic Neuropathy during Assessment in Diabetes Mellitus Patients in PAC

Joseph Swithin Fernando & Sathesh Kumar · Journal of Pharmaceutical Research International · 2021

Background: Diabetes mellitus (DM) is a clinical syndrome characterized by hyperglycaemia due to absolute or relative insulin deficiency. Autonomic neuropathy invokes potentially life threatening outcomes especially in poorly controlled diabetic patients. Objectives: The objectiv...

Open access Research Article 10.9734/jpri/2021/v33i48A33250

A Review on the Reported Antibacterial Activity of 1,3,5-Triazine

Mrinmoy Basak, Biplab Kumar Dey, Sajidul Hoque Ansari, Moksood Ahmed Laskar, Priyanka Goswami, Rosamund Jyrwa, Pal Gogoi & Md. Rejwan Ahmed Choudhury · Journal of Pharmaceutical Research International · 2021

Antibiotics are the class of drugs used for bacterial, viral & fungal infection. Antibiotic resistance is the ability of microorganism to withstand themselves against the effects of a drug. Every year antibiotic resistance causes more than 38000 deaths in Thailand, 23000 deat...

Open access Research Article 10.9734/jpri/2021/v33i48A33251

Incidence of H. pylori in all Endoscopies Done at Saveetha Medical College over the Last Two Years (2018-2020)

S. Kirthika & M. Vinoth · Journal of Pharmaceutical Research International · 2021

Background: H. pylori infection is a major health ailment in most of the developing countries. The infection is associated with increasing morbidity and mortality ranging from chronic gastritis to gastric malignancies. The aim of this study is to assess the prevalence of H. pylor...

Open access Research Article 10.9734/jpri/2021/v33i48A33252

Study to Assess the Severity of Pancreatitis Based on Ranson’s Scoring and Modified CT Severity Index

A. Kishore Khannaa & Agil Selvam · Journal of Pharmaceutical Research International · 2021

Background: Acute pancreatitis is an emergency condition requiring intensive care and 20% of patients fall under the severe category with severe complications and requires early assessment. Objectives: To assess the severity of pancreatitis based on Modified CT severity index and...

Open access Research Article 10.9734/jpri/2021/v33i48B33253

Niosomes: A Promising Drug Delivery System in Transdermal Drug Delivery (TDDS)

Vibhavari M. Chatur & Shashikant N. Dhole · Journal of Pharmaceutical Research International · 2021

Infectious disease treatment and immunisation have undergone a transformative change in recent years. With the advancement of biotechnology and genetic engineering, a large number of disease-specific biological have been created, as well as a focus on delivering these biological...

Open access Research Article 10.9734/jpri/2021/v33i48B33254

Heart Failure Due to Secondary Haemochromatosis in a Case of Beta Thalassemia Major: A Rare Case Presentation

V. V. S. S. Sagar, Maharshi Patel, Pallavi Yelne, Shilpa Gaidhane & Chitturi Venkata Sai Akhil · Journal of Pharmaceutical Research International · 2021

Hemochromatosis is defined as abnormal accumulation of iron in various organs of the body such as liver, pancreas, skin, joints, heart due to raised gut absorption of iron due to low hepcidin yield. Hemochromatosis is secondary to thalassemia major in this case. In the absence of...

Open access Research Article 10.9734/jpri/2021/v33i48B33266

Beliefs and Factors Affecting the Usage and Compliance of Inhalers in Treatment of Asthma in Children

S. Dinesh Bhupathi & . Vidhyasagar · Journal of Pharmaceutical Research International · 2021

Background: Despite the availability of several treatment modalities-various formulations of inhaled corticosteroids and delivery devices, the prevalence of asthma is increasing in the developing countries, especially among the paediatric age group. Though Inhaled corticosteroids...

Open access Research Article 10.9734/jpri/2021/v33i48B33255

Niosomes: A Promising Novel Nano Carrier for Drug Delivery

Nirmal Shah, Rahul Prajapati, Dipti Gohil, Piyush Sadhu & Snehal Patel · Journal of Pharmaceutical Research International · 2021

Niosomes are vesicles, which are formulated by hydrating the mixture of cholesterol, non-ionic surfactant and other biodegradable lipids. Niosomes increase the drug activity as compare to their conventional dosage form of a drug. Niosomes can be used as carrier of amphiphilic and...

Open access Research Article 10.9734/jpri/2021/v33i48B33260

Evaluation of Antibacterial and Antifungal Activities of Crude Extract and Fractions of Morinda citrifolia Fruit on Multiple Drug Resistant Clinical Isolates

Ifeanyichukwu Foster Ene, Ifeoma Bessie Enweani, Monday Uchenna Obaji & Emmanuel Ifeanyi Obeagu · Journal of Pharmaceutical Research International · 2021

Background: Morinda citrifolia fruits are consumed by humans in tropical areas of Africa due to their nutritional and medicinal values. Methods: The fresh fruit of M. citrifolia were harvested, washed with clean water, dried under a shade, pulverized and extracted with methanol i...

Open access Research Article 10.9734/jpri/2021/v33i48B33256

The Administration of Probiotics in Extremely Low-Birth-Weight Infants and the Incidence of Necrotizing Enterocolitis and Mortality: A Systematic Review

Mohammed Khalid Harasani, Sarah Abdulrahman Almosaiteer, Faisal Saleh Aloraini, Saleh Khalid Aldakhil, Jamilah Sulaiman Alsaiari, Abdulrahman Muhaidib Almuhaidib, Omar Muhaidib Almuhaidib, Mohammed Atiah Alisi, Othman Majed Alothman, Thamer Saleh Alanazi & Asalah Tariq Alsaigh · Journal of Pharmaceutical Research International · 2021

Encouraging findings were previously demonstrated in a previous meta-analysis that analyzed the results of randomized controlled trials (RCTs) that investigated the potential favorable effects of probiotics administration in preterm infants to prevent necrotizing enterocolitis (N...

Open access Research Article 10.9734/jpri/2021/v33i48B33269

Antibiotic Susceptibility Patterns of Bacterial Isolates from Infected Wounds in a Tertiary Health Care Center, India

N. Krithik Jain & Rufus Ranjithsingh Edwin · Journal of Pharmaceutical Research International · 2021

Background: An infected wound prolongs the period of stay in hospital which results in further chances of getting affected by nosocomial infection leading to increased number of comorbidities. Hence adequate and appropriate treatment of the infective organism is of prime importan...

Open access Research Article 10.9734/jpri/2021/v33i48B33257