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Research Article Open access CC BY 4.0

The Relationship of HLA-B27 and HLA-B51 on Non-Behcet Uveitis

Ercument Cavdar, Abdullah Ozkaya, Hande Mefkure Ozkaya, Sınan Bılgın, Ozge Elmastas Gultekin, Mustafa Alparslan Babayigit

Ophthalmology Research: An International Journal · pp. 1–8 · Published 24 Sep 2014

10.9734/OR/2015/13047

Abstract

Aims: The aim of this study was to investigate the relationship of human leukocyte antigen (HLA)-B27 and HLA-B51 on the clinical characteristics, demographic features, localization, laterality, treatment modalities and visual prognosis in non-Behcet uveitis patients Study Design: Retrospective study. Place and Duration of Study: Tepecik Eye Training and Research Hospital. January 1999 and March 2009. Methodology: A total of 143 non-Behcet uveitis patients were included. Socio-demographic data and clinical features of the patients were reviewed. The patients were divided into four groups according to HLA-B27 and B-51 positivity which were as follows; HLA B-27 (-) B-51 (-), HLA B-27 (+) B-51 (-), HLA B-27 (-) B-51 (+), and HLA B-27 (+) B-51 (+) groups. Results: Bilateral uveitis and posterior uveitis were more frequent in males in HLA-B27 (+) B51 (+) group, the baseline BCVA values were significantly lower in HLA-B27 (+) B51 (+) group, and also systemic steroid and immunosuppressive treatment were more frequently required to control uveitis attacks in this group. Anterior uveitis was more frequent in the HLA-B27 (-) B51 (-), and HLA-B27 (+) B51 (-) group. Conclusion: The positivity of both HLA-B27 and HLA-B51 was related with worse visual outcomes in non-Behcet uveitis patients associated with requirement of more aggressive treatment. The negativity of both HLA-B27 and HLA-B51 seemed to be related with better visual outcomes and less number of attacks in non-Behcet uveitis patients.  

Behcet disease human leukocyte antigen uveitis

References (18)

  1. 1 Standardization of Uveitis Nomenclature for Reporting Clinical Data. Results of the First International Workshop [DOI]
  2. 2 Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome [DOI]
  3. 3 Uveitis in Behçet disease: An analysis of 880 patients [DOI]
  4. 4 Referral Patterns of Uveitis in a Tertiary Eye Care Center [DOI]
  5. 5 Influence of age of onset and patient's sex on the prevalence and severity of manifestations of Behçet's syndrome. [DOI]
  6. 6 Uveitis: a global perspective [DOI]
  7. 7 Chronic Severe Uveitis [DOI]
  8. 8 Epidemiology of endogenous uveitis in north‐eastern Italy. Analysis of 655 new cases [DOI]
  9. 9 Clinical Features of Acute Anterior Uveitis [DOI]
  10. 10 Clinical Features and Associated Systemic Diseases of HLA-B27 Uveitis [DOI]
  11. 11 Outcomes of HLA-B27-Positive and HLA-B27-Negative Acute Anterior Uveitis [DOI]
  12. 12 Characterization of uveitis associated with spondyloarthritis.
  13. 13 Clinical Features and Outcomes of HLA-B27-Positive and HLA-B27-Negative Acute Anterior Uveitis in a Turkish Patient Population [DOI]
  14. 14 Prognostic Factors of Vision in Patients with Behcet Disease [DOI]
  15. 15 HLA-B27-restricted T cells from patients with ankylosing spondylitis recognize peptides from B*2705 that are similar to bacteria-derived peptides [DOI]
  16. 16 Human Leukocyte Antigen B27 and B51 Double-Positive Behçet Uveitis [DOI]
  17. 17 Etiopathology of BehÇet's disease: immunological aspects [DOI]
  18. 18 Association of HLA‐B51 and lack of association of class II alleles with Behcet's disease [DOI]

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