Skip to content
Research Article Open access CC BY 3.0

Study on Association of Recent and Past Chlamydophila pneumoniae Infection with Classic Multiple Sclerosis

Hamidreza Honarmand, Masoumeh Ahmadi Jalali Moghadam, Hamidreza Hatamian, Ali Roudbary

Microbiology Research Journal International · pp. 1575–1584 · Published 22 Aug 2014

10.9734/BMRJ/2014/9831

Abstract

Aims: We conducted this study to determine if there is any correlation between Classical Multiple Sclerosis and Chlamydophilia pneumoniae infection by ELISA (IgM, IgG, IgA). Study Design: cross sectional study Place and Duration of Study: The present study was performed in the Department of Microbiology, Guilan University of Medical Sciences   between April 2012 and April 2013 Methodology: Chlamydophila pneumoniae infection certified by ELISA in patients (n=46) and control (n=46) using commercial assays (anti- C. pneumoniae IgG, anti- C. pneumoniae IgM, and anti- C. pneumoniae IgA kits). Data were analyzed by using four statistical tests (Pearson chi square, Kendall's tau, and Spearman's rho). Results: Seropositivity to anti- C. pneumoniae IgG was seen less frequently in patients versus controls (69.0% versus 81.4%; P=0.187). Seropositivity to anti- C. pneumoniae IgA  was also observed less frequently in patients than in controls (7.2 % versus 11.6%; P= 0.479).However anti- C. pneumoniae IgM antibodies were seen more often in classical multiple sclerosis patients than it was in controls ( 11.9% versus 2.3%; P= 0.085). Conclusion: We concluded that recent or past C. pneumoniae infection has no correlation in initiation or protection of CMS.

Chlamydophila pneumonia multiple sclerosis anti- C. pneumoniae IgG anti- C. pneumoniae IgM and Anti- C. pneumoniae IgA

References (27)

  1. 1 Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis [DOI]
  2. 2 Autoimmune Diseases: The Failure of Self Tolerance [DOI]
  3. 3 The role of infections in autoimmune disease [DOI]
  4. 4 From Infection to Autoimmunity [DOI]
  5. 5 Chlamydia pneumoniae infection of the central nervous system in multiple sclerosis [DOI]
  6. 6 The Big Idea: Iron-Dependent Inflammation in Venous Disease and Proposed Parallels in Multiple Sclerosis [DOI]
  7. 7 The mosaic of autoimmunity: hormonal and environmental factors involved in autoimmune diseases--2008.
  8. 8 Infections Caused by Chlamydia pneumoniae Strain TWAR [DOI]
  9. 9 Long-term oral azithromycin in chronic plaque psoriasis: a controlled trial [DOI]
  10. 10 Multiple sclerosis associated with Chlamydia pneumoniae infection of the CNS [DOI]
  11. 11 Evidence for infection with Chlamydia pneumoniae in a subgroup of patients with multiple sclerosis [DOI]
  12. 12 Failure to detect Chlamydia pneumoniae in the central nervous system of patients with MS [DOI]
  13. 13 Intrathecal antibody production against Chlamydia pneumoniae in multiple sclerosis is part of a polyspecific immune response [DOI]
  14. 14 Chlamydia pneumoniae in Atherosclerotic Middle Cerebral Artery [DOI]
  15. 15 Under the Microscope: Focus on Chlamydia pneumoniae Infection and Multiple Sclerosis [DOI]
  16. 16 Bacterial infections and the pathogenesis of autoimmune conditions.
  17. 17 Is Chlamydia pneumoniae Present in Brain Lesions of Patients with Multiple Sclerosis? [DOI]
  18. 18 Is Chlamydia pneumoniae found in spinal fluid samples from multiple sclerosis patients? Conflicting results [DOI]
  19. 19 Lack of Chlamydia infection of the central nervous system in multiple sclerosis [DOI]
  20. 20 Acute Chlamydia pneumoniae infection in the pathogenesis of autoimmune diseases [DOI]
  21. 21 Chlamydia pneumoniae Associated with Central Nervous System Infections [DOI]
  22. 22 Chlamydia pneumoniae in the cerebrospinal fluid of patients with multiple sclerosis and neurological controls [DOI]
  23. 23 THE INVESTIGATION OFChlamydophila pneumoniaeIN PATIENTS WITH MULTIPLE SCLEROSIS [DOI]
  24. 24 The pathogenesis of demyelinating disease [DOI]
  25. 25 Multiple Sklerose [DOI]
  26. 26 Multiple sclerosis and Chlamydia pneumoniae [DOI]
  27. 27 Chlamydia pneumoniae and multiple sclerosis: no significant association [DOI]

Cited by 0

No indexed citations yet.

Related research

Article metrics

Real usage data collected on this platform.

63

Page views

0

PDF downloads

17

Outbound clicks

0

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.