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Research Article Open access CC BY 4.0

Incidence of Multi-Drug Resistant among Diarrhoeagenic Children 0-60 Months with Non-Typhoidal Salmonella Organisms Isolated in Selected Hospitals of Bauchi State Metropolis

Ijudai Jasada, A. F. Umar, E. Agbo, Omammegbe Abdulrahman

South Asian Journal of Research in Microbiology · pp. 27–33 · Published 20 Jun 2022

10.9734/sajrm/2022/v12i430284

Abstract

Background: Salmonella non-typhoidal is associated with various gastrointestinal diseases with a significant increase in antibiotic resistance. Antimicrobial resistance is a global public health challenge, which has accelerated by the overuse of antibiotics, causes severe infections, complications, longer hospital stays and increased mortality in the study area. To screen and isolate multi-drug resistant non-typhoidal Salmonella from diarrhoeagenic children aged 0-60 months. Methodology: A total of 222 stool samples were collected from symptomatic diarrhoeagenic children between August-December, 2019 in selected hospitals in Bauchi state metropolis. Samples were subjected to microbiological analysis and antibiotic resistance was determined by the Multiple Antibiotic Resistance (MAR) index.β-lactamase genes were detected by polymerase chain reaction (PCR). A total of 50 isolates of Salmonella obtained and 9 positive isolates of non-typhoidal was obtained respectively. Non-typhoidal Salmonella were discovered to be more prevalence among age between 48-60 months (37.50%), male children (62.50%), outpatients (62.50%) and more prevalence among patient attending Bauchi State Specialist Hospital (33.33%). Results: The results of antimicrobial susceptibility of the commonly used and prescribed antibiotics showed that, 87.5% of the non-typhoidal Salmonella were resistant to cloxacillin, followed by 75% to tetracycline and 75% to chloramphenicol. Multiple antibiotic resistance (MAR) index of the non-typhoidal Salmonella in this study shows that 62.5% have MAR index of ≥ 0.5, this indicate a significant level of misuse of these antibiotics. The result revealed a positive correlation and the relationship was statistically significant (0.005) at 1% level of significant. The polymerase chain reaction (PCR) detected tetA gene and tetB gene. Conclusion: The study demonstrated a relatively high level of gene mediated antibiotic resistance to tetracycline and other antibiotics. The high prevalence and increased resistance especially among non-typhoidal Salmonella is a cause of concern and reiterates the need for extensive routine checks along with stool samples for better management of gastroenteritis.

Non-typhoidal Salmonella multi-drug resistance PCR tetA tetB genes antibiotics

References (12)

  1. 1 Bulletin of the World Health Organization
  2. 2 District Laboratory Practice in Tropical Countries [DOI]
  3. 3 Koneman's Color Atlas and Textbook of Diagnostic Microbiology
  4. 4 Systematic Review and Meta-Analysis of the Efficacy of Appropriate Empiric Antibiotic Therapy for Sepsis [DOI]
  5. 5 Procalcitonin Test in the Diagnosis of Bacteremia: A Meta-analysis [DOI]
  6. 6 Multidrug-Resistant Typhoid Fever With Neurologic Findings on the Malawi-Mozambique Border [DOI]
  7. 7 Molecular epidemiology of fluoroquinolone resistant Salmonella in Africa: A systematic review and meta-analysis [DOI]
  8. 8 Epidemiology of bacterial resistance in gastro-intestinal pathogens in a tropical area [DOI]
  9. 9 Textbook of microbiology [DOI]
  10. 10 Detection of blaCTX-M-15 extended-spectrum β-lactamase genes in Escherichia coli from hospital patients in Nigeria [DOI]
  11. 11 Bacterial Isolates in the Sick Young Infant in Ile-Ife, Nigeria [DOI]
  12. 12 Fluoroquinolone-resistant Salmonella typhi infection: a report of two cases in South Africa [DOI]

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