Glycaemic Evaluation of Murraya koenigii in Alloxan-induced Diabetic Rabbits
T. Akande, S. T. Balogun, H. Abdullahi, T. O. Ogundeko, M. S. Ramyil
International Journal of Biochemistry Research & Review · pp. 175–181 · Published 25 May 2015
10.9734/IJBCRR/2015/17529Abstract
Glycaemic Evaluation of Murraya koenigii in Alloxan-induced Diabetic Rabbits Background: Study was aimed to evaluate the antidiabetic activity of Murraya koenigii, a traditional medicinal plant (Curry leaf) in normoglycemic and alloxan-induced diabetes rabbits. Methods: Antidiabetic activity of aqueous extract of M. koenigii in 100, 200 300 mg/k doses was determined by estimating blood glucose before and at 1, 2, 4, 8, 24, and 72 hours post treatment intervals in treated rabbits. Results: Aqueous extract of Murraya koenigii showed a dose dependent antidiabetic activity with maximum effect established at 300 mg/kg. The extract also exhibited a significant (p<0.05) dose- dependent hypoglycemic effect on normal and alloxan-induced diabetic rabbits. Conclusion: Murraya koenigii causes a reduction in blood glucose. This hypoglycemic property supports-its usein folkloric medicine as an antidiabetic agent and thus suggests a place for it in nutritional therapy in the management of diabetes mellitus and thus as an oral hypoglycaemic agent.
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