Skip to content
Research Article Open access CC BY 4.0

Evaluation of the Anti-virulent Potentials of Ginger (Zingiber officinale L) and Garlic (Allium sativum) on S. aureus and P. aeruginosa

Robinson, V. K., Minimah S. O., Ifegwu M. K., Akinido C. E.

South Asian Journal of Research in Microbiology · pp. 56–64 · Published 1 May 2024

10.9734/sajrm/2024/v18i5367

Abstract

The degree of a pathogen to cause infection is termed virulence. Anti-virulence substances are substances that could inhibit the expression of virulence by these pathogens thereby limiting the degree of diseases caused. The study aimed to evaluate the anti-virulence of Zingiber officinale and Allium sativum on S. aureus and P. aeruginosa. The Methicillin-resistant Staphylococcus aureus and Carbapenem-resistant Pseudomonas aeruginosa associated with clinical specimens were collected from the Microbiology Research Laboratory, Department of Microbiology, Rivers State University. The extracts of Zingiber officinale and Allium sativum were prepared using standard method. The virulence considered included lecithinase, biofilm formation, coagulase, swarming, haemolysis and pyocyanin. Thus, the inhibition of this virulence as well as curring the isolates was carried out using standard method. Results showed that 30, 10, 20 and 20% of the S. aureus isolates were inhibited by the ginger extract from producing haemolysis, biofilm, coagulase and lecithinase, respectively. While 10%, 20%, 10% and 30% of the isolates were inhibited after treatment with garlic extract. For P. aeruginosa, 20%, 30%, 40%, 20% and 40% were inhibited by ginger extract from producing haemolysin, biofilm, lecithinase, pyocyanin and swarming, respectively. The susceptibility tests after curring with the extracts and acridine orange showed that both S. aureus and P. aeruginosa were susceptible to some of the antibiotics they resisted before. The spices having shown anti-virulence properties against these pathogens, they could be evaluated for better options in the fight against bacterial pathogens and antimicrobial resistance.

Anti-virulence Zingiber officinale Allium sativum S. aureus P. aeruginosa

References (12)

  1. 1 Non-traditional Antibacterial Therapeutic Options and Challenges [DOI]
  2. 2 Antimicrobial effect of different herbal plant extracts against different microbial population [DOI]
  3. 3 Leaf Extracts of Mangifera indica L. Inhibit Quorum Sensing – Regulated Production of Virulence Factors and Biofilm in Test Bacteria [DOI]
  4. 4 Malabaricone C from Myristica cinnamomea Exhibits Anti-Quorum Sensing Activity [DOI]
  5. 5 Hemolysins of Staphylococcus aureus—An Update on Their Biology, Role in Pathogenesis and as Targets for Anti-Virulence Therapy [DOI]
  6. 6 Medicinal plants extracts affect virulence factors expression and biofilm formation by the uropathogenic Escherichia coli [DOI]
  7. 7 An insight of traditional plasmid curing in Vibrio species [DOI]
  8. 8 Fresh Garlic Extract Enhances the Antimicrobial Activities of Antibiotics on Resistant Strains in Vitro [DOI]
  9. 9 Doxycycline interferes with quorum sensing-mediated virulence factors and biofilm formation in Gram-negative bacteria [DOI]
  10. 10 Assessment of the anti-virulence potential of extracts from four plants used in traditional Chinese medicine against multidrug-resistant pathogens [DOI]
  11. 11 The Effects of Chinese Herbal Medicines on the Quorum Sensing-Regulated Virulence in Pseudomonas aeruginosa PAO1 [DOI]
  12. 12 The concept for the antivirulence therapeutics approach as alternative to antibiotics: hope or still a fiction? [DOI]

Cited by 4

Antibacterial and Motility-Modulating Activities of Red Ginger (Zingiber officinale Roscoe var. rubrum) Extract

Ratna Yuliani, Maryati Maryati, Anniesa Chaerani · Tropical Journal of Natural Product Research · 2026

Showing 1 of 4 known citations — external sources report more than can currently be individually listed.

Related research

Article metrics

Real usage data collected on this platform.

54

Page views

0

PDF downloads

18

Outbound clicks

4

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.