Effects of Virgin Coconut Oil on Aluminium Chloride-Induced Alzheimer-Like Dementia in the Prefrontal Cortex
J. A. Olanrewaju, O. B. Akinola, S. Y. Olatunji, J. O. Owolabi, O. S. Fabiyi, U. E. Ukonne, A. B. O. Desalu
Journal of Advances in Medical and Pharmaceutical Sciences · pp. 1–12 · Published 29 Sep 2018
10.9734/JAMPS/2018/35221Abstract
Aims: The aim of this investigation is to study the effect of virgin coconut oil on the prefrontal cortex upon aluminium chloride-induced Alzheimer- likes dementia. Study Design and Methodology: Twenty-eight (28) adult male Wistar rats were used and were randomly assigned into four groups: Group A: Considered to be the control group which took water and food daily. Group B: Virgin coconut oil treated group, were administered virgin coconut oil orally with 1700 mg/kg BW for 42 days. Group C: Aluminium chloride treated group, were administered Aluminium chloride orally with 200 mg/kg BW for 42 days. Group D: Aluminium chloride + virgin coconut oil treated group, the Wistar rats were administered Aluminium chloride orally with 200 mg/BW for 21 days and then virgin coconut oil orally with 1700 mg/BW for the next 21 days. The neurobehavioural investigation was done after the experiment to evaluate learning and memory using Barnes Maze. Animals were sacrificed by cervical dislocation. The whole brain was carefully excised from the skull. Prefrontal cortex was removed and fixed in 10% formal saline for histological analysis which includes H&E stain for general histoarchitecture and Cresyl fast violet for Nissl substance. Place and Duration of Study: The study was done in Babcock University and approved by the Babcock University Ethics commission (BUHREC) with the BUHREC number 672/16. The experiment took the total of 45 days. Results: Neurobehavioral study revealed a significant high latency in the animals treated with Aluminium chloride when compared with control and other treated groups. H &E technique, as well as Cresyl fast violet, did not show any observable altered morphological presentation in the control and VCO treated groups. Also, a cellular density between the control and virgin coconut oil group appears normal across the cortical layers with appreciable spines and neuronal projections. The Aluminium chloride treated group induced degenerative changes in the cortex and was characterized by fragmented pyramidal and granule cell layer with observable pyknotic cells. Also, there was a comparatively increased cell density in the cortical layers of the VCO and Aluminium chloride + VCO treated groups. Conclusion: Findings from this study support the view that, virgin coconut oil has ameliorative effects which neutralize the adverse effect of Aluminum chloride and tried to restore the integrity of the prefrontal cortex.
References (18)
- 1 Alzheimer's Disease: Genes, Proteins, and Therapy [DOI]
- 2 Testing Predictions From Personality Neuroscience [DOI]
- 3 Prefrontal structural and functional brain imaging findings in antisocial, violent, and psychopathic individuals: A meta-analysis [DOI]
- 4 Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial [DOI]
- 5 The prefrontal cortex: categories, concepts and cognition [DOI]
- 6 Frontal Cortex and the Discovery of Abstract Action Rules [DOI]
- 7 Effects of a Saturated Fat and High Cholesterol Diet on Memory and Hippocampal Morphology in the Middle-Aged Rat [DOI]
- 8 Plasma n−3 fatty acids and the risk of cognitive decline in older adults: the Atherosclerosis Risk in Communities Study [DOI]
- 9 The role of dietary coconut for the prevention and treatment of Alzheimer's disease: potential mechanisms of action [DOI]
- 10 Early-onset Alzheimer's Disease: Nonamnestic Subtypes and Type 2 AD [DOI]
- 11 n−3 Fatty acid proportions in plasma and cognitive performance in older adults [DOI]
- 12 Potential Impact of Amyloid Imaging on Diagnosis and Intended Management in Patients With Progressive Cognitive Decline [DOI]
- 13 EXPERIMENTAL PRODUCTION OF NEUROFIBRILLARY DEGENERATION [DOI]
- 14 Properties and Stability of Oil-in-Water Emulsions Stabilized by Coconut Skim Milk Proteins [DOI]
- 15 Run-On Gene Transcription in Human Neocortical Nuclei: Inhibition by Nanomolar Aluminum and Implications for Neurodegenerative Disease [DOI]
- 16 Long-term monitoring of the ketogenic diet: Do's and Don’ts [DOI]
- 17 PTEN deletion enhances survival, neurite outgrowth and function of dopamine neuron grafts to MitoPark mice [DOI]
- 18 Demulsification of Virgin Coconut Oil by Centrifugation Method: A Feasibility Study [DOI]
Cited by 15
Devesh Kapoor, Deepak Sharma, J.B. Sharma · Nutraceutical Fruits and Foods for Neurodegenerative Disorders · 2024
Siong Meng Lim, Nur Syafiqah Rahim, Kalavathy Ramasamy · Oxidative Stress and Dietary Antioxidants in Neurological Diseases · 2020
Olanrewaju John Afees, Owolabi Joshua Oladele, Simon Peniel Oluwatoni · Phytomedicine Plus · 2021
John Afees Olanrewaju, Okoro Iheanyichukwu, Owolabi Joshua Oladele · Phytomedicine Plus · 2022
Stephen Taiye Adelodun, Oluwadamilola Adunni Ishola, Ayodeji Zabdiel Abijo · Phytomedicine Plus · 2021
Showing 5 of 15 known citations — external sources report more than can currently be individually listed.
Related research
- Intervention is Urgently Needed to Address Poor Awareness of South Asian Family Caregivers for Dementia Care: A Qualitative Study — shares topic coverage
- Overview of Diabetes as a Risk Factor for Developing Dementia: A Systematic Review — shares topic coverage
- Preparation of Herbal Products (Brahmi, Ashwagandha and Curcumin) Using Plant Extract to Cure Dementia Patients — shares topic coverage
- Sensory Garden for Occupational Therapy and Improving Quality of Life — shares topic coverage
- A High-p/Low-p Procedure to Improve Recall Memory in Elderly Patients with Mild to Moderate Cognitive Impairment — shares topic coverage
Article metrics
Real usage data collected on this platform.
68
Page views
0
PDF downloads
47
Outbound clicks
15
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.