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Cancer Initiation and Progression: A Comprehensive Review of Carcinogenic Substances, Anti-Cancer Therapies, and Regulatory Frameworks

Aadil Shafi Bhat, Mizna Ahmed, Kashif Abbas, Mohd Mustafa, Mudassir Alam, Mansour A.S. Salem, Sidra Islam, Irfan Qadir Tantry, Yogendra Singh, Muizzah Fatima, Nazura Usmani, Mohd Faraz, Mohammad Afeef, Safia Habib

Asian Journal of Research in Biochemistry · pp. 111–125 · Published 22 Jun 2024

10.9734/ajrb/2024/v14i4300

Abstract

Cancer is a multifaceted disease influenced by genetic mutations and environmental factors, including exposure to carcinogens. This review presents an in-depth analysis of the mechanisms driving cancer initiation, focusing on the roles of carcinogenic chemicals, anticancer therapies, and chemo-preventive agents. The discussion encompasses a broad spectrum of carcinogens: chemical agents like polycyclic aromatic hydrocarbons, physical agents such as ionizing radiation, biological agents like viruses, and certain therapeutic drugs. The multistep nature of carcinogenesis—comprising initiation, promotion, and progression phases—is detailed, with an emphasis on genetic and epigenetic alterations. Methods for testing carcinogenicity, including in vitro and in vivo studies and epidemiological approaches, are highlighted for their significance in identifying potential carcinogens and understanding their mechanisms. To classify and regulate carcinogenic exposures, the review also looks at the risk management plans and regulatory frameworks used by agencies like the European Chemicals Agency (ECHA), the Environmental Protection Agency (EPA), and the International Agency for Research on Cancer (IARC). Additionally, emerging trends in cancer treatment, such as precision oncology, immunotherapy, and early detection technologies, are explored, alongside ongoing challenges like health disparities and ethical issues. The review emphasizes the necessity of a multidisciplinary approach, involving collaboration among researchers, clinicians, regulatory bodies, and public health organizations, to translate scientific findings into effective cancer prevention, detection, and treatment strategies.

Carcinogens carcinogenesis chemical carcinogens cancer risk environmental factors targeted therapies mutagenesis regulatory oversight

References (91)

  1. 1 Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases [DOI]
  2. 2 Arsenic: toxicity, oxidative stress and human disease [DOI]
  3. 3 Inflammation and cancer [DOI]
  4. 4 Molecular Mechanisms of Ultraviolet Radiation‐Induced DNA Damage and Repair [DOI]
  5. 5 Molecular targeted therapy: Treating cancer with specificity [DOI]
  6. 6 Effects of Ionizing Radiation on Biological Molecules—Mechanisms of Damage and Emerging Methods of Detection [DOI]
  7. 7 Review of cancer from perspective of molecular [DOI]
  8. 8 Hypoxia-Inducible Factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia.
  9. 9 Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis [DOI]
  10. 10 Biological response of cancer cells to radiation treatment [DOI]
  11. 11 Epigenetic modifications in cancer [DOI]
  12. 12 Matrix Metalloproteinase-Induced Epithelial-Mesenchymal Transition in Breast Cancer [DOI]
  13. 13 Toxic and genotoxic effects of hexavalent chromium in environment and its bioremediation strategies [DOI]
  14. 14 Inflammation-induced DNA damage, mutations and cancer [DOI]
  15. 15 DNA repair mechanisms in cancer development and therapy [DOI]
  16. 16 Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition [DOI]
  17. 17 Various modes of cell death induced by DNA damage [DOI]
  18. 18 A Review of the Toxicology of Acrylamide [DOI]
  19. 19 Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer [DOI]
  20. 20 Carcinogens and DNA damage [DOI]
  21. 21 DNA Damage Induced by Alkylating Agents and Repair Pathways [DOI]
  22. 22 Repair of Topoisomerase I‐Mediated DNA Damage [DOI]
  23. 23 Overview of mechanisms of cancer chemopreventive agents [DOI]
  24. 24 Natural products: An upcoming therapeutic approach to cancer [DOI]
  25. 25 The Redox Role of G6PD in Cell Growth, Cell Death, and Cancer [DOI]
  26. 26 Environmental factors inducing human cancers.
  27. 27 Vinyl Chloride: Still a Cause for Concern [DOI]
  28. 28 Cancer and Heart Disease: Associations and Relations [DOI]
  29. 29 Viral Oncology: Molecular Biology and Pathogenesis [DOI]
  30. 30 Stroke among cancer patients [DOI]
  31. 31 Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy [DOI]
  32. 32 Viral Carcinogenesis: Factors Inducing DNA Damage and Virus Integration [DOI]
  33. 33 Cellular and Molecular Mechanisms Underlying Prostate Cancer Development: Therapeutic Implications [DOI]
  34. 34 Alkylating agents and cancer therapy [DOI]
  35. 35 Carcinogenicity assessment: Addressing the challenges of cancer and chemicals in the environment [DOI]
  36. 36 The role of cytochrome P450 enzymes in carcinogen activation and detoxication: an in vivo–in vitro paradox [DOI]
  37. 37 Genetic and environmental factors in cancer and neurodegenerative diseases [DOI]
  38. 38 Classification schemes for carcinogenicity based on hazard-identification have become outmoded and serve neither science nor society [DOI]
  39. 39 Oncoapoptotic signaling and deregulated target genes in cancers: Special reference to oral cancer [DOI]
  40. 40 Primary Immunodeficiency and Cancer Predisposition Revisited: Embedding Two Closely Related Concepts Into an Integrative Conceptual Framework [DOI]
  41. 41 Factors to consider in the use of stem cells for pharmaceutic drug development and for chemical safety assessment [DOI]
  42. 42 Coal Fly Ash Aerosol: Risk Factor for Lung Cancer [DOI]
  43. 43 Synergistic and additive effects of ATRA in combination with different anti-tumor compounds [DOI]
  44. 44 The NTP Report on Carcinogens: A valuable resource for public health, a challenge for regulatory science [DOI]
  45. 45 The Tumor Promoter 12-O-Tetradecanoylphorbol 13-acetate (TPA) Provokes a Prolonged Morphologic Response and ERK Activation in Tsc2-Null Renal Tumor Cells [DOI]
  46. 46 Traditional Ayurvedic medicines: Pathway to develop anti-cancer drugs [DOI]
  47. 47 Acute exposure of human lung cells to 1,3-butadiene diepoxide results in G1 and G2 cell cycle arrest [DOI]
  48. 48 Industry and geographic patterns of use and emission of carcinogens in Ontario, Canada, 2011–2015 [DOI]
  49. 49 Cancer Drug Discovery: Science and History [DOI]
  50. 50 Environmental and Occupational Interventions for Primary Prevention of Cancer: A Cross-Sectorial Policy Framework [DOI]
  51. 51 Inflammation and tumor progression: signaling pathways and targeted intervention [DOI]
  52. 52 Metabolic reprogramming and cancer progression [DOI]
  53. 53 Breast Cancer Statistics, 2022 [DOI]
  54. 54 Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation [DOI]
  55. 55 DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy [DOI]
  56. 56 The Role of Tumor Microenvironment in Cancer Metastasis: Molecular Mechanisms and Therapeutic Opportunities [DOI]
  57. 57 Insights Into the Role of Matrix Metalloproteinases in Cancer and its Various Therapeutic Aspects: A Review [DOI]
  58. 58 Tumour predisposition and cancer syndromes as models to study gene–environment interactions [DOI]
  59. 59 Heavy metals exposure, carcinogenic and non-carcinogenic human health risks assessment of groundwater around mines in Joghatai, Iran [DOI]
  60. 60 Impact of Gene–Environment Interactions on Cancer Development [DOI]
  61. 61 Mechanisms of Regulated Cell Death: Current Perspectives [DOI]
  62. 62 Arsenic and cancer: Evidence and mechanisms [DOI]
  63. 63 Tumor Suppressors Having Oncogenic Functions: The Double Agents [DOI]
  64. 64 Unboxing the molecular modalities of mutagens in cancer [DOI]
  65. 65 The Role of Bioactive Compounds in Natural Products Extracted from Plants in Cancer Treatment and Their Mechanisms Related to Anticancer Effects [DOI]
  66. 66 Addressing Cancer Disparities Through Community Engagement: Lessons and Best Practices [DOI]
  67. 67 Cancer Evolution: A Multifaceted Affair [DOI]
  68. 68 Immunomodulatory effect of mushrooms and their bioactive compounds in cancer: A comprehensive review [DOI]
  69. 69 Nuclear DNA damages generated by reactive oxygen molecules (ROS) under oxidative stress and their relevance to human cancers, including ionizing radiation-induced neoplasia part I: Physical, chemical and molecular biology aspects [DOI]
  70. 70 Genetic Variation and its Role in Malignancy [DOI]
  71. 71 Assessing chemical carcinogenicity: hazard identification, classification, and risk assessment. Insight from a Toxicology Forum state-of-the-science workshop [DOI]
  72. 72 Repurposing Antidepressants and Phenothiazine Antipsychotics as Efflux Pump Inhibitors in Cancer and Infectious Diseases [DOI]
  73. 73 The hallmarks of aging in Ataxia-Telangiectasia [DOI]
  74. 74 DNA Damage/Repair Management in Cancers [DOI]
  75. 75 Research Recommendations for Selected IARC-Classified Agents: Impact and Lessons Learned [DOI]
  76. 76 DNA Damaged Induced Cell Death in Oocytes [DOI]
  77. 77 Epigenetic Effects of Benzene in Hematologic Neoplasms: The Altered Gene Expression [DOI]
  78. 78 A comprehensive review of mechanistic insights into formaldehyde-induced nasal cavity carcinogenicity [DOI]
  79. 79 DNA damage in cancer development: special implications in viral oncogenesis.
  80. 80 Thresholds for carcinogens [DOI]
  81. 81 Recent Updates on Viral Oncogenesis: Available Preventive and Therapeutic Entities [DOI]
  82. 82 In Vitro Approaches to Determine the Potential Carcinogenic Risk of Environmental Pollutants [DOI]
  83. 83 Comparison of the roles of estrogens and androgens in breast cancer and prostate cancer [DOI]
  84. 84 Investigation of phytoextraction and tolerance capacity of Calotropis procera for the detoxification of hexavalent chromium, nickel, and lead [DOI]
  85. 85 Histone methylation in pre-cancerous liver diseases and hepatocellular carcinoma: recent overview [DOI]
  86. 86 Crosstalk between cancer stem cells and the tumor microenvironment drives progression of premalignant oral epithelium [DOI]
  87. 87 Evaluation of the Suitability of Mammalian In Vitro Assays to Assess the Genotoxic Potential of Food Contact Materials [DOI]
  88. 88 Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract Derivatives [DOI]
  89. 89 Transcription Factor E2F1 Knockout Promotes Mice White Adipose Tissue Browning Through Autophagy Inhibition [DOI]
  90. 90 A Comprehensive Review on the Formation of Carcinogens from Food Products with Respect to Different Cooking Methods [DOI]
  91. 91 International meeting on cancer chemoprevention: molecular basis, mechanisms and trials [DOI]

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