Skip to content
Research Article Open access CC BY 4.0

Bioactivity Assessment of Analgesic and Anti-inflammatory Properties of Eclipta prostrata Extract on Rat Models

Md Shakil, Md Shirajul Islam, Sadiya Binte Rashid, Samiun Islam, Aklima Akter, Nowrin Tasnia Khan Mysha, Zulqarnain Haider, Bushratul Jannat, Sadia Tasnim, Mohammad Hasnat Ahmed, Sadia Azim

Asian Journal of Advanced Research and Reports · pp. 226–236 · Published 15 May 2025

10.9734/ajarr/2025/v19i51014

Abstract

Medicinal plants have traditionally been used to prevent and treat a range of health concerns. Numerous plant extracts have demonstrated anti-inflammatory and pain-relieving effects. In this study, the alcoholic extract of Eclipta prostrata was assessed for its potential analgesic and anti-inflammatory properties. Our investigation is crucial to discovering more effective and safe bioactive substitute to synthetic drugs in treating pain and inflammation.  The analgesic efficacy of the Eclipta prostrata extract was evaluated using the acetic acid-induced writhing test and the tail-flick method. At the same time, its anti-inflammatory activity was determined based on its effect on carrageenan-induced paw edema. Eclipta prostrata extended the reaction time of rats to nociceptive stimuli in a dose-dependent manner. The extract had the most effective anti-inflammatory response when supplied at 600 mg/kg dosage at three and 6-hour intervals, while other dosages yielded no statistically significant results. The extract of Eclipta prostrata mitigated acetic acid-induced paw irritation in rats at a dosage of 900 mg/kg. There were no statistically significant effects on analgesic action at any other dosages except 900 mg/kg. The tail flick technique demonstrated that a 900 mg/kg dosage of the extract was statistically significant (p < 0.05) at both the 3-hour- and 4-hour intervals. According to our findings, the extract of Eclipta prostrata exhibits substantial anti-inflammatory and analgesic properties, which must be investigated in further research.

Herbal medicine Eclipta prostrata analgesic anti-inflammatory carrageenan tail-flick method

References (12)

  1. 1 Methods Used to Evaluate Pain Behaviors in Rodents [DOI]
  2. 2 A review on traditional uses, phytochemistry and pharmacology of Eclipta prostrata (L.) L. [DOI]
  3. 3 In Vivo and In Silico Assessment of Diabetes Ameliorating Potentiality and Safety Profile of Gynura procumbens Leaves [DOI]
  4. 4 Assessment of the Chemical Profile and Potential Medical Effects of a Flavonoid-Rich Extract of Eclipta prostrata L. Collected in the Central Highlands of Vietnam [DOI]
  5. 5 A review of ethnomedicinal uses, phytochemistry, nutritional values, and pharmacological activities of Hylocereus polyrhizus [DOI]
  6. 6 Anti-Inflammatory Potential and Synergic Activities of Eclipta prostrata (L.) L. Leaf-Derived Ointment Formulation in Combination with the Non-Steroidal Anti-Inflammatory Drug Diclofenac in Suppressing Atopic Dermatitis (AD) [DOI]
  7. 7 Uses of Complementary and Alternative Medicine in Multiple Sclerosis [DOI]
  8. 8 Extraction Process, Component Analysis, and In Vitro Antioxidant, Antibacterial, and Anti-Inflammatory Activities of Total Flavonoid Extracts from Abutilon theophrasti Medic. Leaves [DOI]
  9. 9 Anti-inflammatory effects of Eclipta prostrata Linné on house dust mite-induced atopic dermatitis in vivo and in vitro [DOI]
  10. 10 A methanolic extract of Eclipta prostrata (L.) L. decreases inflammation in a murine model of chronic allergic asthma via inhibition of the NF-kappa-B pathway [DOI]
  11. 11 Chemical Composition Analysis and Assessment of Antioxidant and Anti-Inflammatory Activities of Crude Extract of Flueggea leucopyrus on Carrageenan-Induced Paw Edema in Wistar Albino Rats [DOI]
  12. 12 Analgesic Activities of Methanol Extract of Terminalia chebula Fruit [DOI]

Cited by 1

Exploring the Potential of Eclipta Alba against S. Typhi: Harnessing Nature Power for Health

Mojabir Hussen Ansaree, G. Soni, Mojabir Hussen · International Journal of Drug Delivery Technology · 2026

Related research

Article metrics

Real usage data collected on this platform.

67

Page views

0

PDF downloads

42

Outbound clicks

1

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.