Lekara John

Metformin Ameliorates Cognitive Impairment and Hippocampal Oxidative Damage in Iron Dextran-induced Oxidative Stress in Male Wistar Rats

Uduak A. Inwang, Daisy Dominic, Kubiat T. Umana, Nze P. Odunnaya, Emmanuel O. Nwuzor, Peter O. Odu, Bakumor S. Yolo, Emmanuel I. Obi & Lekara John · Asian Journal of Research and Reports in Neurology · 2026

Metformin, a first-line therapy for type 2 diabetes mellitus, is increasingly recognised for pleiotropic effects beyond glycaemic control, including potential neuroprotection. However, whether metformin protects cognition under mild iron-related oxidative stress remains unclear....