Yasumaru Hatanaka

Simple Synthesis of Sulfonyl Amidine-Containing Glucosidase Inhibitors by a Chemoselective Coupling Reaction Between D-Gluconothiolactam and Sulfonyl Azides

Muhammad Aswad, Junya Chiba, Takenori Tomohiro & Yasumaru Hatanaka · International Research Journal of Pure and Applied Chemistry · 2017

In this report, we describe a simple synthesis of gluconoamidinylsulfones as a new class of potential inhibitors toward glycan processing enzymes. Gluconoamidinylsulfones have a glucose-based sulfonyl amidine skeleton, thus would form a distorted half-chair conformation with posi...