Wim Dehaen, Michal Szostak & Huaping Xu · Organics · 2020
Organic chemistry is near to entering its third century, if one dates the Wöhler experiment (1828) as the starting point [...]
Temitayo Omowumi Alegbejo Price, Flavio Emery & Wim Dehaen · Organics · 2022
Pyrido[3,4-c]pyridazines are nitrogen-containing scaffolds that have been described as being promising in medicinal chemistry, but they are rather rare chemicals. In this review article, the literature on synthetic pathways towards pyrido[3,4-c]pyridazines is listed exhaustively,...
Rebecca Hermans, Max Van Hoof, Luc Van Meervelt & Wim Dehaen · Organics · 2023
The Nenitzescu reaction is a condensation reaction between an enamine and a quinone, which can give rise to a wide variety of reaction products depending on the nature of the starting material and the reaction conditions. The most commonly observed products are 5-hydroxyindoles a...
Tomas Opsomer, Kaat Valkeneers, Ana Ratković & Wim Dehaen · Organics · 2021
1,2,3-Triazole-4-carbaldehydes are useful synthetic intermediates which may play an important role in the discovery of novel applications of the 1,2,3-triazole moiety. In this work, a one-step multigram scale synthesis of 4-formyl-1-(4-nitrophenyl)-1H-1,2,3-triazole (FNPT) as a p...
Pieterjan Winant, Tomas Horsten, Shaiani Gil de Melo, Flavio Emery & Wim Dehaen · Organics · 2021
Dihydropyrrolo[1,2-a]pyrazinone rings are a class of heterocycles present in a wide range of bioactive natural products and analogues thereof. As a direct result of their bioactivity, the synthesis of this privileged class of compounds has been extensively studied. This review pr...