Wenjie Nie

Physiological Indicators of Paeoniflorin and Caffeine in Modulating the Motility of Caenorhabditis elegans Via Adenosine Receptor

Wenjie Nie, Shuning Hu, Sudan Ye & Chun Chen · Annual Research & Review in Biology · 2025

Aims: Paeoniflorin exhibits a broad range of in vitro and in vivo pharmacological effects. However, its potential as a drug targeting adenosine receptors remains largely unexplored. Methodology: In this study, the wild-type N2 strain and the Ador-1 gene knockout EG6890 strain of...

Open access Research Article 10.9734/arrb/2025/v40i42219

Effects of Adenosine and Lactate Coexistence on NK92 Cell

Xinjie Xu, Wenjie Nie, Fangfang Ding & Chun Chen · Annual Research & Review in Biology · 2024

Aims: This study aims to investigate the impact of lactate and adenosine, present in the tumor microenvironment (TME), on the immune cell immunity. Methodology: Five groups included Adenosine concentration screening groups, L-lactic acid and Sodium L-lactate concentration groups,...

Open access Research Article 10.9734/arrb/2024/v39i32062

Lactic Acid Inhibits the Cytotoxicity of NK-92 Cells via Activating the Lactate Receptor GPR81

Yaobiao Huang, Wenjie Nie, Sudan Ye & Chun Chen · Annual Research & Review in Biology · 2023

Aims: Lactate acid functions as not only an energy source but a signaling molecule through the lactate receptor GPR81 under physiological conditions. However, the pathological role of lactic acid in the tumor microenvironment remains unclear, particularly for immune cells. Method...

Open access Research Article 10.9734/arrb/2023/v38i330573