Veeraswami Boddu

Development and Validation of Three Potential Genotoxic Impurities by Liquid Chromatography Single Quad Mass Detector in Iomeprol

Rayala Rama Rao, Gundapaneni Ravi Kumar, Vadde Megha Vardhan & Veeraswami Boddu · Journal of Pharmaceutical Research International · 2021

A liquid chromatography with single quadrupole mass detection method was developed for the determination of potential genotoxic impurities (PGIs) in the Iomeprol active pharmaceutical ingredient. Chromatographic separation was achieved on an Agilent Eclipse plus C8 column (100 mm...

Open access Research Article 10.9734/jpri/2021/v33i47A33071

A Simple and Sensitive LC-MS/MS Method for Determination and Quantification of Potential Genotoxic Impurities in the Vismodegib Active Pharmaceutical Ingredient

Rayala Rama Rao, Gundapaneni Ravi Kumar, Vadde Megha Vardhan & Veeraswami Boddu · Journal of Pharmaceutical Research International · 2021

A rapid and sensitive LC-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantitative analysis of four potential genotoxic impurities Imp-A (2-chloro-5-nitroaniline), Imp-B (1-chloro-2-iodo-4-nitrobenzene), Imp-C (1-(2-chloro-5-nitrophenyl)ethan-1-o...

Open access Research Article 10.9734/jpri/2021/v33i44B32654