Takenori Tomohiro

Simple Synthesis of Sulfonyl Amidine-Containing Glucosidase Inhibitors by a Chemoselective Coupling Reaction Between D-Gluconothiolactam and Sulfonyl Azides

Muhammad Aswad, Junya Chiba, Takenori Tomohiro & Yasumaru Hatanaka · International Research Journal of Pure and Applied Chemistry · 2017

In this report, we describe a simple synthesis of gluconoamidinylsulfones as a new class of potential inhibitors toward glycan processing enzymes. Gluconoamidinylsulfones have a glucose-based sulfonyl amidine skeleton, thus would form a distorted half-chair conformation with posi...

Open access Research Article 10.9734/IRJPAC/2017/34259

Neighboring Nitrogen Atom-Induced Reactions of Azidoacetyl Hydrazides, including Unexpected Nitrogen-Nitrogen Bond Cleavage of the Hydrazide

Hiroki Tanimoto, Ryo Adachi, Aoi Otsuki & Takenori Tomohiro · Organics · 2022

We studied the hydrazide compounds of the α-azidoacetyl group, which showed specific click reactivity by the intramolecular hydrogen bonding between the azido group and the N-H of the hydrazide moiety. In the competitive click reactions with a general alkyl azide, both traceless...

Open access Research Article 10.3390/org3040035