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Sunil K. Joshi

Publications (5)

A Novel Single-Pot Process for the Efficient Synthesis of Nonivamide: Detailed Stoichiometric Engineering, Reaction Mechanism, and Comparative NMR Characterization with Capsaicin

Hemanth Kumar Manikyam, Sunil K. Joshi & P. Venkata Suresh · Journal of Scientific Research and Reports · 2026

Nonivamide (N-(4-hydroxy-3-methoxybenzyl) nonanamide), also known as pelargonic acid vanillylamide (PAVA), is an industrially important synthetic capsaicinoid with potent transient receptor potential vanilloid subtype-1 (TRPV1) agonistic activity and extensive applications in pha...

Open access Research Article 10.9734/jsrr/2026/v32i94512

Integrated PEF–Supercritical CO₂ Technology for High-Purity Astaxanthin Extraction from Haematococcus pluvialis

Hemanth Kumar Manikyam, Sunil K. Joshi & P. Venkata Suresh · Journal of Scientific Research and Reports · 2026

Astaxanthin, a high-value xanthophyll carotenoid with potent antioxidant activity, was efficiently extracted from the microalga Haematococcus pluvialis using an integrated green extraction strategy combining pulsed electric field (PEF)-assisted cell disruption and supercritical C...

Open access Research Article 10.9734/jsrr/2026/v32i54168

Multi-Pathway Inhibition by Rosmarinic Acid in Endometritis: Intrinsic Network Pharmacology and Molecular Docking Insights

Hemanth Kumar Manikyam & Sunil K. Joshi · Journal of Pharmaceutical Research International · 2025

A systematic Intrinsic network pharmacology methodology was employed to determine the multi-target therapeutic activity of Rosmarinic acid in endometritis. Prediction of target proteins was performed using Swiss Target Prediction and PharmMapper, followed by protein–protein inter...

Open access Research Article 10.9734/jpri/2025/v37i97748

Intrinsic Network Pharmacology Guided Simulation of NAFLD Collapse and Recovery: A Systems Level Investigation of Picrorhiza Kurroa via Multi Layered Network Integration

Hemanth Kumar Manikyam & Sunil K. Joshi · Journal of Pharmaceutical Research International · 2025

Non-alcoholic fatty liver disease (NAFLD) is a significant world health burden, occurring in more than 25% of the adult population and advancing to steatohepatitis, fibrosis, and eventually cirrhosis or hepatocellular carcinoma. Although it is increasingly prevalent, there are li...

Open access Research Article 10.9734/jpri/2025/v37i77721

Intrinsic Network Pharmacology for Mapping Divergent System Trajectories: Computational Study of Rasayana Induced Restoration and Deficiency Driven Collapse

Hemanth Kumar Manikyam & Sunil K. Joshi · Archives of Current Research International · 2025

Contemporary chronic diseases, including pervasive Vitamin D3 and B12 deficiencies, are increasingly considered failures of intricate metabolic and regulatory networks—rather than isolated biochemical imbalance. Deficiencies interrupt integrated processes such as redox signaling,...

Open access Research Article 10.9734/acri/2025/v25i61281