Effect of Cyclophosphamide and Its Combination with Metformin on the Survival Rate in Mice
Ahmad Alhowail, Sultan Sajid, Yasser Almogbel, S. I. Rabbani & Mansour Alsharidah · Journal of Pharmaceutical Research International · 2019
Background: Cyclophosphamide (CYP), an alkylating chemotherapeutic agent, is widely used to treat several types of cancer. Its toxic effects are well-established and include hepatotoxicity, nephrotoxicity, and bone marrow suppression. Metformin (MET) is an anti-diabetic medicatio...