Formulation Design and Optimization of Hydrophilic Matrix Based Sustained Release Tablet of Clarithromycin Using a Design of Experiment (DoE)
Tirtha Nandi, Uttom Kumar, Subrata Bhadra & Abu Shara Shamsur Rouf · Journal of Advances in Medicine and Medical Research · 2022
A well-defined and strictly controlled dissolution rate plays vital role in optimization of sustained release dosage form. For this purpose, a computer optimized technique, based on a response surface methodology (RSM) utilizing a quadratic equation and factorial design has been...