Breast cancer is the most common diagnosed cancer and the leading cause of related death in woman across the world. Nowadays, there are many effective chemotherapeutic agents used in the treatment of breast cancer, however due to the high side effects of these drugs, there is sti...
Open access
Research Article10.9734/jpri/2019/v28i530217
Computational chemistry is a unique method in the drug discovery process?? Explain Why?. In this study 109 molecules containing the isatin backbone were subjected to quantitative structure-activity relationship analysis to find the structure requirements for ligand binding. The s...
Open access
Research Article10.9734/jpri/2019/v27i530184
Aims: Isatin is a honored scaffold and one of the most favorable class of heterocyclic systems that possesses many interesting biological activities and well-tolerated in humans. Here a series of fifteen spirooxindole-4H-pyran derivatives containing both isatin and pyran moieties...
Open access
Research Article10.9734/jpri/2019/v31i630364
Aims: Recently the use of antifungal drugs in human medicine has been increased, especially with the advent of AIDS epidemic. The extensive use of antifungal drugs and their resistance against fungal infections have led to the discovery of new antimicrobial compounds. Despite the...
Open access
Research Article10.9734/JPRI/2017/38244
Aims: The development of new beneficial agents is one of the crucial aims in medicinal chemistry. Isatin is considered as a vital class of bioactive compounds exhibiting different biological activities. A series of nine new Semicarbazone (12a-i) and six new Thiosemicarbazone (14a...
Open access
Research Article10.9734/JPRI/2017/35243