Bioanalytical Method Validation of LC–MS/MS Assays for Trazodone: A Critical Review Based on USFDA and ICH M10 Guidelines
Vaishnavi Dhangude, Shrikrishna Baokar, Rajendra Patil & Mansingh Rajput · Journal of Pharmaceutical Research International · 2026
Trazodone (TZD) is widely used for the treatment of major depressive disorder, anxiety-related disorders, and insomnia. Accurate quantification of TZD in biological matrices is essential for pharmacokinetic, bioavailability, and bioequivalence studies. Liquid chromatography coupl...