Global Variation in Female Pubertal Onset, Progression, and Duration, and Biochemical Thresholds for Diagnosis: A Comparative Review across Continents and Gonadotropin–estradiol Cutoffs
Ashraf Soliman, Fawzia Alyafei, Nada Alaaraj, Noor Hamed, Shayma Mohamed & Nada Soliman · Asian Journal of Research and Reports in Endocrinology · 2026
Background: Female pubertal onset is a complex, multifactorial biological event with substantial global variation. Secular trends show progressive earlier thelarche and menarche across continents, yet biochemical thresholds for diagnosing pubertal onset and central precocious pub...
Open access
Research Article
10.9734/ajrre/2026/v9i1132