Sharmy Saimon Mano

Extracellular Matrix Mechanics in Cancer: Mechanotransduction, Cellular Phenotype, and Therapeutic Resistance

Sharmy Saimon Mano · Asian Oncology Research Journal · 2026

Abnormal extracellular matrix (ECM) stiffening emerges chiefly from enhanced matrix deposition and remodelling by cancer cells and cancer-associated fibroblasts. This biomechanical alteration activates mechanosensitive pathways, principally through integrin-mediated adhesion comp...

Open access Research Article 10.9734/aorj/2026/v9i1152

Molecular Crosstalk between Cancer Stem Cells and the Tumor Microenvironment: Therapeutic Implications

Sharmy Saimon Mano · Asian Oncology Research Journal · 2025

The dynamic interaction between cancer stem cells (CSCs) and the tumor microenvironment (TME) is increasingly recognized as a key driver of tumor progression, metastasis, and therapeutic resistance. Disrupting this molecular crosstalk offers a promising strategy to improve cancer...

Open access Research Article 10.9734/aorj/2025/v8i1104