Boosting Terbinafine Solubility through Hot Melt Extrusion Coprocessing Guided by QbD
Edna Alcantara-Fierro, Rodolfo Pinal, Efrén Hernandez-Baltazar, Sergio Alcala-Alcala, Teresa Carvajal, Fernando Alvaréz-Nuñez & Mariana Ortiz-Reynoso · Journal of Pharmaceutical Research International · 2025
The formulation of hydrophobic drugs, such as terbinafine hydrochloride (TbHCl), presents significant challenges due to their low aqueous solubility, which severely limits oral bioavailability. This study explores the application of hot-melt extrusion (HME) to enhance the dissolu...
Open access
Research Article
10.9734/jpri/2025/v37i107760