Sandeep Balvant Patil

High-Throughput Insilico Drug Screen against Mpox Targeted Proteins in Comparison with Repurposed Antiviral Drugs against Natural Compounds

Hemanth Kumar Manikyam, Sandeep Balvant Patil, Nazim Hussain, R. Edison Eegai Vallal, Shikha Sharma & Abhinandan Ravsaheb Patil · Journal of Pharmaceutical Research International · 2024

The recent resurgence of the Monkeypox Virus (MPXV) has prompted increased efforts to discover effective antiviral treatments. This study utilized an in silico docking approach with CB Dock2 to assess both natural compounds and repurposed antiviral medications. We concentrated on...

Open access Research Article 10.9734/jpri/2024/v36i117599

Simultaneous Extraction, Purification, and Quantification of Polyphenols, Caffeine, and Theophylline from BB35 Green Tea Leaves (Kenya cultivar) Using High-Performance Liquid Chromatography (HPLC) with Gradient Quantification

Hemanth Kumar Manikyam, Cecilliah N Ngugi, Fridah Marete, Elizabeth Kagotho, Sandeep Balvant Patil & Abhinandan Ravsaheb Patil · South Asian Research Journal of Natural Products · 2024

This study introduces a novel technique that uses a solvent mixture of 60% water and 40% ethanol to extract caffeine, theophylline, and polyphenols from green tea leaves (Camellia sinensis) all at once. On a dry basis, the Folin-Ciocalteu Reagent Method (ISO 14502-1) estimated th...

Open access Research Article 10.9734/sarjnp/2024/v7i3172

Microwave Assisted Extraction of Berberine and Preparation of Berberine Hydrochloride from Berberis Aristata Variety of Nepal, and Quantification using RP-HPLC and HPTLC Methods

Hemanth Kumar Manikyam, Prathibha Tripathi, Jyoti Joshi, Jayaram Balasubramanian, Sandeep Balvant Patil, Trishna Lamichhane & Janardan Lamichhane · European Journal of Medicinal Plants · 2021

Berberis aristata a Himalayan woody spiny shrub with yellow flowers and red berries commonly called as Daruharidra in Sanskrit and locally in Nepal is called as Chutro or Chitra. The root and stem are the two parts widely used in traditional medicines of India and China. Berberin...

Open access Research Article 10.9734/ejmp/2021/v32i1230434