Synthetic Methods and Process Approaches to Betulin 3,28-Diacetate: From Birch Bark to Semi-Synthetic Derivatives
Aigerim Zhaxybayeva, Khava Yevloyeva, Saltanat Kaliyeva, Nurgul Nurmukhanbetova, Idiya Ostretsova, Nazira Kassenova, Dana Kazyakhmetova & Aziza Yeskendirova · Organics · 2026
Betulin, a lupane-type pentacyclic triterpene abundant in birch bark, is an accessible renewable scaffold for semisynthetic chemistry, while its 3,28-diacetate serves both as an isolable derivative and as a protected intermediate for further functionalization. This review critica...
Research Article
10.3390/org7040040