Acid Catalyzed N-Alkylation of Pyrazoles with Trichloroacetimidates
Rowan I. L. Meador, Nilamber A. Mate & John D. Chisholm · Organics · 2022
N-Alkyl pyrazoles are important heterocycles in organic and medicinal chemistry, demonstrating a wide range of biological activity. A new method for the N-alkylation of pyrazoles has been developed using trichloroacetimidate electrophiles and a Brønsted acid catalyst. These react...
Open access
Research Article
10.3390/org3020009