Computational chemistry is unique method in drug discovery which reduce cost. In this study 86 molecules containing isatin core were subjected to quantitative structure-activity relationship analysis and docking study to find the structure requirements for ligand binding. The str...
Open access
Research Article10.9734/jpri/2019/v31i530314
Computational chemistry is a unique method in the drug discovery process?? Explain Why?. In this study 109 molecules containing the isatin backbone were subjected to quantitative structure-activity relationship analysis to find the structure requirements for ligand binding. The s...
Open access
Research Article10.9734/jpri/2019/v27i530184
The HIV-1 reverse transcriptase (RT) is a major target for drug development. Inhibition of this enzyme has been one of the primary therapeutic strategies in suppressing the replication of HIV-1. A series of 2-amino-6-arylsulfonylbenzonitrile derivatives were subjected to quantita...
Open access
Research Article10.9734/ajacr/2018/v1i29617
Breast cancer is the most common diagnosed cancer and the leading cause of related death in woman across the world. Nowadays, there are many effective chemotherapeutic agents used in the treatment of breast cancer, however due to the high side effects of these drugs, there is sti...
Open access
Research Article10.9734/jpri/2019/v28i530217
Type 2 diabetes (T2DM) is a metabolic disorder disease and DPP-4 inhibitors are a class of oral hypoglycemic that blocks the dipeptidyl peptidase-4 (DPP-4) enzyme. DPP-4 inhibitors reduce glucagon and blood glucose levels and don’t have side effects such as hypoglycemia or weigh...
Open access
Research Article10.9734/jpri/2019/v27i630186
Aims: The development of new beneficial agents is one of the crucial aims in medicinal chemistry. Isatin is considered as a vital class of bioactive compounds exhibiting different biological activities. A series of nine new Semicarbazone (12a-i) and six new Thiosemicarbazone (14a...
Open access
Research Article10.9734/JPRI/2017/35243