Paulo Eduardo da Silva Bastos

A Nanotoxicological Approach to the Effects of Metformin and Sodium Metavanadate Co-encapsulated in Polycaprolactone Nanoparticles under the Biological Parameters of Zebrafish (Danio rerio)

Tiago Queiroz da Mota Bittencourt, Thamiris Pinheiros Santos, Paulo Eduardo da Silva Bastos, Marleyne José Afonso Accioly Lins Amorim, Sâmara da Silva Gomes, Yuri Mateus Lima de Albuquerque & Pabyton Gonçalves Cadena · Archives of Current Research International · 2024

The present study evaluated the sublethal and lethal effects, and heart rate of Danio rerio when exposed to antidiabetic drugs, metformin (M-10), and sodium metavanadate (V-10), their association (MV-10) and the polycaprolactone nanoparticles containing poloxamer 188 with (PPMV-1...

Open access Research Article 10.9734/acri/2024/v24i121007

Rotenone-treated in the Early Life Stages of Zebrafish (Danio rerio) as a Model for Parkinson-like Motor and Non-motor Symptoms and Anxiety-like Behaviour

André Lucas Correa de Andrade, Renatta Priscilla Ferreira Silva, Priscila Rafaela Leão Soares, Thamiris Pinheiro Santos, Renata Meireles Oliveira Padilha, Paulo Eduardo da Silva Bastos & Pabyton Gonçalves Cadena · Archives of Current Research International · 2025

Background: Rotenone is a pesticide derived from a natural toxin present in plants and is used in agriculture and aquaculture to eliminate unwanted fish. The toxicity of rotenone in fish makes it difficult to determine an optimal dose that efficiently reduces dopaminergic neurons...

Open access Research Article 10.9734/acri/2025/v25i71369