Timed Administration of Febuxostat Improved Testicular Function Following Testicular Ischemia-reperfusion Injury Via Inhibition of MDA/NO Pathway, Down-regulation of Toll-like Receptor 4 Expression and Restoration of Reproductive Hormones
Oreoluwa Janet Adedeji, Oladele Ayobami Afolabi, Richard Adedamola Ajike, Olubunmi Simeone Oyekunle, Waidi Adeoye Saka, Olajumoke Deborah Ogunleye, Bamidele Oluwole Olusola, Oluwaseun Samuel Hezekiah, Sodiq Opeyemi Hammed & Babatunde Adebola Alabi · Journal of Advances in Biology & Biotechnology · 2024
Introduction: Testicular ischemia-reperfusion injury (TIRI) generates reactive oxygen species (ROS) through xanthine oxidase (XO) activity in the ischemic phase and leukocyte infiltration to the site of injury during reperfusion leading to oxidative stress, inflammation, and disr...
Open access
Research Article
10.9734/jabb/2024/v27i121800