Obi Frances Somtochukwu

Annona muricata Ethanolic Leaf Extract Attenuates Dexamethasone Induced Oxidative Stress, Dyslipidemia and Hepatotoxicity in Rats through Upregulation of Endogenous Antioxidant Enzymes and Lipid Profile Normalization

Obi Ifeanyi Malachy, Chilaka Kingsley Chimsorom, Obi Helen Chinonyelum, Chilaka Jane Ugochinyere, Obi Frances Somtochukwu & Imolede Ohiomoje Isaac · Asian Journal of Medical Principles and Clinical Practice · 2026

Background: The therapeutic use of dexamethasone is often associated with adverse effects such as oxidative stress, dyslipidemia, and hepatotoxicity, primarily due to the generation of reactive oxygen species and disruption of metabolic homeostasis. Natural plant‑based antioxidan...

Open access Research Article 10.9734/ajmpcp/2026/v9i2450

Annona muricata Ethanolic Leaf Extract Ameliorates Dexamethasone-induced Hypertension in Rats via Angiotensin-Converting Enzyme Inhibition, Sustained Systolic Blood Pressure Reduction and Renin-angiotensin System Modulation

Obi Ifeanyi Malachy, Chilaka Kingsley Chimsorom, Obi Helen Chinonyelum, Chilaka Jane Ugochinyere, Obi Frances Somtochukwu & Imolede Ohiomoje Isaac · Journal of Complementary and Alternative Medical Research · 2026

Hypertension is a major global health challenge and a leading risk factor for cardiovascular diseases. It is commonly associated with activation of the renin–angiotensin system (RAS), oxidative stress, and metabolic disturbances, which contribute to the progression of cardiovascu...

Open access Research Article 10.9734/jocamr/2026/v27i4750