N'goran Urbain Florent Niangoran

Structure-Based Design and In silico Evaluation of Novel Donepezil Analogues as Potent Inhibitors of Human Acetylcholinesterase for Alzheimer's Disease Therapy

Issouf Fofana, Aboubakar Traoré, Bafétigué Ouattara, Akassa Marius Bernard Djako, N'goran Urbain Florent Niangoran, Souleymane Konate & Eugene Megnassan · Journal of Pharmaceutical Research International · 2025

Alzheimer's disease (AD) accounts for 60 to 70% of dementias worldwide. This condition is primarily associated with the decrease in acetylcholine (ACh) levels, due to the action of human acetylcholinesterase (AChE). The lack of a curative treatment for Alzheimer's disease undersc...