Mikhail A. Kalinin

Bispidine-Based Macrocycles: Achievements and Perspectives

Aleksei V. Medved’ko, Savelii V. Gaisen, Mikhail A. Kalinin & Sergey Z. Vatsadze · Organics · 2023

This review presents all currently known macroheterocyclic compounds that include a bispidine (3,7-diazabicyclo[3.3.1]nonane) fragment in their structure. A classification of bispidine-containing macroheterocycles, which is based on the ring size and the nature of bispidinic nitr...

Open access Research Article 10.3390/org4030030

Synthesis of Bispidine-Based Prostate-Specific Membrane Antigen-Targeted Conjugate and Initial Investigations

Aleksei E. Machulkin, Stanislav A. Petrov, Maria D. Kraynova, Anastasiia S. Garanina, Bayirta V. Egorova, Roman V. Timoshenko, Alexander N. Vaneev, Alexander S. Erofeev, Anna B. Priselkova, Mikhail A. Kalinin, Aleksei V. Medved’ko, Stepan N. Kalmykov, Elena K. Beloglazkina & Sergey Z. Vatsadze · Organics · 2025

Nowadays, PSMA ligands are widely used for radiotheragnostic purposes in prostate cancer. The synthesis of a PSMA-Bisp conjugate was developed and realized with good yield (overall yield ~58% for the last two steps). All newly synthesized compounds were characterized by physicoch...

Open access Research Article 10.3390/org6010007