Synthesis of 23,23-Difluoro-24-nor- and 24′,24′-Difluoro-24-Homovitamin D3 Analogues and Unexpected Structure-Activity Relationships
Fumihiro Kawagoe, Hiroya Tabuchi, Taiyo Ideguchi, Yuki Okamoto, Souma Murata, Tomofumi Yatsu, Syota Yamada, Kaori Yasuda, Yusuke Akagi, Masashi Takano, Toshie Fujishima, Yoshiki Miyata, Ken’ichi Aoki, Toshiyuki Sakaki & Atsushi Kittaka · Organics · 2026
We synthesized two vitamin D3 analogues, 3 and 4, which have a shortened or elongated fluoro-side-chain based on 24,24-difluoro-25-hydroxyvitamin D3 (5) using an efficient convergent approach and studied their preliminary biological activity. Both analogues exhibited greater resi...
Open access
Research Article
10.3390/org7020018