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Maria Claudia Santos-Silva

Publications (4)

Detection of Metastatic Breast Carcinoma Cells in Bone Marrow by Flow Cytometry

Manoela Lira Reis, Daniella Serafin Couto Vieira, Laura Otto Walter & Maria Claudia Santos-Silva · International Journal of Medical and Pharmaceutical Case Reports · 2019

Breast cancer is the most common cause of cancer death in women worldwide. Cytological, histological, and immunohistochemical techniques are routine laboratory tests for determining tumor subtypes. Over the past few years, laboratory diagnostic tests for breast cancer have become...

Open access Research Article 10.9734/ijmpcr/2019/v12i330105

Flow Cytometric Detection of CK19-Positive Circulating Tumor Cells in Bone Marrow and Peripheral Blood in Metastatic Breast Cancer: A Case Report

Maria Eduarda Cunha-Silva, Heloísa Zorzi Costa, Íris Mattos Santos-Pirath, Chandra Chiappin Cardoso, Daniella Serafin Couto Vieira & Maria Claudia Santos-Silva · International Journal of Medical and Pharmaceutical Case Reports · 2026

Metastatic breast cancer represents the most advanced stage, where the accurate and rapid identification of neoplastic cells is essential for clinical management and prognostic assessment. Although immunohistochemistry is the gold standard, flow cytometry emerges as a robust and...

Open access Research Article 10.9734/ijmpcr/2026/v19i2489

B-Cell Acute Lymphoblastic Leukemia Associated with Isolated and Recurrent Central Nervous System Relapse with a Novel t(6;19)(q21;p13) Translocation: A Case Report

Heloísa Zorzi Costa, Maria Eduarda Cunha-Silva, Andressa Oliveira Martin Wagner, Íris Mattos Santos-Pirath, Chandra Chiappin Cardoso, Sharbel Weidner Maluf & Maria Claudia Santos-Silva · International Journal of Medical and Pharmaceutical Case Reports · 2026

B-cell acute lymphoblastic leukaemia (B-ALL) is a haematological malignancy characterised by the clonal proliferation of B-lymphoid precursors. Cytogenetic and molecular alterations are central to B-ALL classification and diagnosis according to the 2024 World Health Organization...

Open access Research Article 10.9734/ijmpcr/2026/v19i4527

Diagnosis of Therapy-related Acute Myeloid Leukemia with t(8;21)(q22;q22.1) after Treatment for Mantle Cell Lymphoma and Oral Squamous Cell Carcinoma

Patrícia Colombo Corrêa, Íris Mattos Santos-Pirath, Chandra Chiappin Cardoso, Camila Mattiolo, Bruno Vieira Dias, Mariana Franzoni Maioral & Maria Claudia Santos-Silva · International Journal of Medical and Pharmaceutical Case Reports · 2019

Aims: We report a rare case of therapy-related AML with t(8;21)(q22;q22.1) that occurred after treatment for mantle cell lymphoma (MCL) and oral squamous cell carcinoma (OSCC). Presentation of Case: A 52 years-old male patient was diagnosed with MCL in leukemic phase. The treatme...

Open access Research Article 10.9734/ijmpcr/2019/v12i230104