Malachy C. Ugwu

Extended-Spectrum Beta-Lactamase-Producing Uropathogens in Pediatric UTIs: Molecular Characteristics, Clinical Impact and Public Health Consequences

Nzube F. Ekpunobi, Malachy C. Ugwu, Kingsley C. Agu, Chukwunwejim, C. R, Eddison Igho Oghonyon, Temitope Ogunmola, Oluwabunmi Seun Ajasa, Sandra Chiamaka Okoye & Nwasoluchukwu Obidi · Journal of Advances in Biology & Biotechnology · 2025

Urinary tract infections (UTIs) remain a common and serious health challenge among pediatric populations, particularly in low- and middle-income countries. The emergence of extended-spectrum beta-lactamase (ESBL)-producing uropathogens significantly complicates treatment, increas...

Open access Research Article 10.9734/jabb/2025/v28i92918

Factors Affecting Treatment Outcomes among Tuberculosis Patients during 2019- 2024: A Study from a University Teaching Hospital in South Eastern Nigeria

Chioma V. Francis, Nzube F. Ekpunobi, Nwasoluchukwu Obidi, Chidozie N. Ibezim & Malachy C. Ugwu · Journal of Advances in Medical and Pharmaceutical Sciences · 2025

Background: Tuberculosis (TB) remains a major public health problem in Nigeria, where treatment success is impacted by various factors including poor adherence, adverse drug effects, and systemic barriers. Understanding local treatment outcomes and associated factors are essentia...

Open access Research Article 10.9734/jamps/2025/v27i11830

Bridging Viral Oncology and Precision Medicine: Leveraging Molecular Signatures of Oncoviruses for Liquid Biopsies and Non-invasive Surveillance

Nzube F. Ekpunobi, Chidimma R. Chukwunwejim, Oghonyon I. Eddison, Sandra C. Okoye, Theresa Ariri, Michael Kyere & Malachy C. Ugwu · Journal of Scientific Research and Reports · 2026

Oncogenic viruses contribute substantially to the global burden of malignancy and remain an important challenge for cancer prevention, early detection, and surveillance. This review examines the molecular signatures associated with major oncogenic viruses, including human papillo...

Open access Research Article 10.9734/jsrr/2026/v32i94477

Antibiogram of Vulvovaginal Candidiasis amongst Pharmacy Undergraduates in a Nigerian University

Angus N. Oli, Chiamaka B. Ugwu, Eunice O. Osuala, Charlotte Blanche Oguejiofor, George Uchenna Eleje, Felix N. Osuala & Malachy C. Ugwu · Journal of Advances in Medicine and Medical Research · 2017

Objectives: To assess the knowledge, perception, incidence and the antibiogram of vulvovaginal candidiasis (VVC).   Methods: Validated questionnaires were used to collect demographic information of consenting study participants and to test the participants’ level of knowledge and...

Open access Research Article 10.9734/JAMMR/2017/33340

Co-occurrence of Quinolone Resistance (Qnr) Genes and ESBL (CTX-M) in Uropathogenic Klebsiella pneumoniae and Escherichia coli from Patients in Onitsha, Nigeria

Uchechukwu G. Mgbedo, Ugochukwu M. Okezie, Chidimma R. Chukwunwejim, Ijeoma N. Ebenebe, Nzube F. Ekpunobi, Ezinne Janefrances umeh, Sandra C. Okoye, Lydia C. Okoye, Moses N. Ikegbunam & Malachy C. Ugwu · Journal of Advances in Biology & Biotechnology · 2025

Escherichia coli and Klebsiella pneumoniae are leading uropathogens, with rising resistance to fluoroquinolones and β-lactams posing major treatment challenges. The co-occurrence of plasmid-mediated quinolone resistance (PMQR) genes and extended-spectrum β-lactamase (ESBL) determ...

Open access Research Article 10.9734/jabb/2025/v28i123428