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M. O. Nwokike

Publications (9)

A Review on Alcohol Temperance in Health and Disease

M. O. Nwokike, A. O. Ogbonna, M. N. Ezenwaeze, C. A. Anusiem & S. I. Ghasi · Journal of Advances in Medicine and Medical Research · 2022

There is hardly a disagreement about the dangers of alcoholism ranging from addiction through cardiovascular disorders and cancers to death. But there seem to be conflicting science and sense on the effect of low to moderate intake of alcohol and abstinence in health and disease....

Open access Research Article 10.9734/jammr/2022/v34i244918

Extrapyramidal Symptoms and Novel Antipsychotic Drugs

M. O. Nwokike, S. I. Ghasi, A. O. Ogbonna, M. N. Ezenwaeze & A. C. Ezinwa · International Neuropsychiatric Disease Journal · 2022

One of the challenges of antipsychotic medication is the occurrence of Extrapyramidal Symptoms. These cannot be easily eliminated considering the pathophysiology of schizophrenia and the established mechanism of action of classical antipsychotics. The antipsychotics help improve...

Open access Research Article 10.9734/indj/2022/v17i430207

An Appraisal of the Drug Discovery Process in Neuroscience

M. O. Nwokike, S. I. Ghasi, M. N. Ezenwaeze, A. O. Ogbonna, A. C. Ezinwa & C. C. Offor · International Neuropsychiatric Disease Journal · 2022

The scientific study of the nervous system is a major area for disease and consequently disease management. The use of drugs to treat neurological disease is the backbone of this sphere of therapy. This review will concentrate of the history, process, constraints and novelty of d...

Open access Research Article 10.9734/indj/2022/v17i230195

Hepatic Enzyme Effects of an Imperata cylindrica Extract

M. O. Nwokike, S. I. Ghasi, E. C. Ogbuagu, M. N. Ezenwaeze & Akpotu E. Ajirioghene · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2021

This study was performed to investigate the effects of aqueous Imperata cylindrica root extract on hepatic enzyme levels of alloxan-induced diabetic male Wistar rats. Forty (48) male wistar rats were divided into six groups consisting of eight animals each. Diabetes mellitus was...

Open access Research Article 10.9734/ajrimps/2021/v10i330168

Examining the Androgenic Effect of Different Imperata Cylindrica Extracts on Diabetic Wistar Rats

M. O. Nwokike, S. I. Ghasi, A. O. Ogbonna, C. A. Anusiem, C. C. Ofor, E. C. Ogbuagu, M. N. Ezenwaeze & Akpotu E. Ajirioghene · European Journal of Medicinal Plants · 2021

This was an experimental study that evaluated the effect of aqueous, methanol and chloroform root extracts of Imperata cylindrica on serum levels of testosterone in male Wistar rats. Shade dried Imperata cylindrica roots were pounded and crude extracts prepared using distilled wa...

Open access Research Article 10.9734/ejmp/2021/v32i630396

Neuronal Control of Pituitary Function

M. O. Nwokike, A. U. Mbah, A. O. Ogbonna & S. I. Ghasi · Asian Journal of Research and Reports in Endocrinology · 2021

The pituitary gland secretes a collection of hormones that jointly influence all cells and affect virtually all physiologic processes. The anterior pituitary (also called the adenohypophysis or pars anterior), is the glandular, anterior lobe that together with the posterior lobe...

Open access Research Article 10.9734/ajrre/2021/v4i132

Immune Competency in a Coronavirus Environment

M. O. Nwokike, A. O. Ogbonna, C. A. Anusiem, E. C. Ogbuagu & S. I. Ghasi · Asian Journal of Immunology · 2021

Coronavirus disease 2019 [COVID-19] belongs to the class of coronaviruses - one of a group of RNA[ribonucleic acid] viruses that infect animals and humans, primarily the upper respiratory and gastrointestinal tract and these are zoonotic, meaning that they can be transmitted betw...

Open access Research Article

The Abuse of Central Nervous System Stimulants and its Impact on the Youth of Eastern Nigeria

M. O. Nwokike, C. A. Anusiem, C. O. Arinze & A. O. Ogbonna · International Neuropsychiatric Disease Journal · 2021

The class of drugs designated as central nervous system (CNS) stimulants includes the four social drugs that find use among some youth of Eastern Nigeria; caffeine, nicotine, cocaine and marijuana. CNS stimulants increase or enhance the activity of monoamines (such as dopamine an...

Open access Research Article 10.9734/indj/2021/v15i330156