Evidence of Interaction between PTPN22 and p53 codon 72 Polymorphisms on Susceptibility to Immune Related Diseases
F. Gloria-Bottini, P. Saccucci, M. L. Manca-Bitti, N. Rapini, A. Neri, L. Coppeta, G. Renzetti, E. Bottini & A. Magrini · Journal of Advances in Medicine and Medical Research · 2013
Background: PTPN22 codifies for a protein-tyrosine-phosphatase (Lyp) involved in T cell receptor signaling regulation. p53 is involved in immune related inflammation regulating STAT 1 and pro-inflammatory cytokines. Possible interaction between the two systems concerning the susc...
Open access
Research Article
10.9734/BJMMR/2013/2888