Jack R. Wall

Risk Factors for the Development of Ophthalmopathy in Patients with Hashimoto’s Thyroiditis

Ilhem El Kochairi, Bernard Champion & Jack R. Wall · Ophthalmology Research: An International Journal · 2014

Background: Ophthalmopathy, or thyroid eye disease (TED), is more often associated with Graves’ hyperthyroidism than Hashimoto’s thyroiditis. In the latter disorder, the pathogenesis of the eye signs may be different and the influence of well-known risk factors for the developmen...

Open access Research Article 10.9734/OR/2014/4562

Calsequestrin is Decreased in the Thyroid Gland of Patients with Graves’ Disease – Further Evidence for a Role of Autoimmunity against this Protein in Graves’ Ophthalmopathy

Daniele Cultrone, Hooshang Lahooti, Senarath Edirimanne, Leigh Delbridge, Bernard Champion & Jack R. Wall · Journal of Advances in Medicine and Medical Research · 2014

Background: The pathogenesis of Graves’ ophthalmopathy (GO) and the mechanism for its link to thyroid autoimmunity is poorly understood. Our present research focuses on the role of the skeletal muscle calcium binding protein calsequestrin (CASQ1). Earlier studies showed that the...

Open access Research Article 10.9734/BJMMR/2014/9504

Association of the CASQ1 Gene SNP rs3838216 with Graves’ Ophthalmopathy and Hashimoto’s Thyroiditis in Patients with Thyroid Autoimmunity

Hooshang Lahooti, Daniele Cultrone, Senarath Edirimanne, John P. Walsh, Leigh Delbridge, Patrick Cregan, Bernard Champion & Jack R. Wall · Ophthalmology Research: An International Journal · 2014

The pathogenesis of Graves’ ophthalmopathy is poorly understood, but there is evidence for the involvement of calsequestrin (CASQ1) as an autoantigen. Aim: To compare the frequency of the single nucleotide polymorphism (SNP) rs3838216 (located in intron 1 of CASQ1) in patients wi...

Open access Research Article 10.9734/OR/2014/10623