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Iffan Alif

Publications (5)

The Role of MSC-Derived Exosomes in Soft Tissue Remodelling via the PTEN and PI3K/AKT Pathway Following Wide Excision of Fibrosarcoma: A Review

Joko Wibowo Sentoso, Agung Putra, Iffan Alif & Henky Agung Nugroho · Asian Journal of Medicine and Health · 2025

Fibrosarcoma is a neoplasm of fibroblast tissue with varying collagen production. Fibrosarcoma, an aggressive form of soft tissue cancer, is currently a major challenge in the field of oncology. Although its prevalence is relatively low compared to other cancers, fibrosarcoma's s...

Open access Research Article 10.9734/ajmah/2025/v23i11156

Optimization of PD-1 / PD-L1 Blockade to Increase NK Cells Cytotoxicity in Killing Cancer Cells: Article Review

Joko Wibowo Sentoso, Agung Putra & Iffan Alif · Journal of Cancer and Tumor International · 2024

Anti-PD-1 and anti-PD-L1 are therapies that have shown success in cancer treatment. However, while treating cancer with PD-1/PD-L1 blockade is similar, the clinical response rate is still low in certain cancers at around 40%. Therefore, therapeutic strategies are needed to increa...

Open access Research Article 10.9734/jcti/2024/v14i1248

Targeting Unique Features of Quiescent Cancer Stem Cells to Overcome Resistance and Recurrence in Cancer Therapy: A Review

Joko Wibowo Sentoso, Agung Putra & Iffan Alif · Journal of Cancer and Tumor International · 2024

Quiescent cancer stem cells (QCSC) are non-proliferating cells that survive in the G0 phase and have low ki-67 expression and high p27 expression. QCSCs have the ability to evade most chemotherapy, and some subsequent treatments may result in a higher proportion of quiescent canc...

Open access Research Article 10.9734/jcti/2024/v14i1247

Apoptotic Effects of Adipose-Derived Stem Cell Secretome in Breast Cancer Stem Cells: A Literature Review

Joko Wibowo Sentoso, Agung Putra & Iffan Alif · Journal of Cancer and Tumor International · 2024

Adipose-derived stem cells (ASC) are cells from the core of fat tissue that secrete various cytokines, growth factors, proteins and extracellular vesicles that can be used in regenerative therapy, especially in the case of cancer. This ASC produces a secretome which is an exosome...

Open access Research Article 10.9734/jcti/2024/v14i1244

The Role of Adipose-derived Stem Cell in Breast Reconstruction with Fat Grafting: A Literature Review

Joko Wibowo Sentoso, Agung Putra & Iffan Alif · Journal of Cancer and Tumor International · 2023

Adipose-derived stem cells (ADSC) are a biological development that provides new hope regarding tissue engineering and regenerative therapy. Due to its potential paracrine activity, compounding, paracrine activity and immunomodulatory function, ADSC-based cell-assisted lipotransf...

Open access Research Article 10.9734/jcti/2023/v13i3-4245