Hooshang Lahooti

Reactivity against the Flavine Adenosine Nucleotide (FAD) Cofactor of Bacterial Enzymes May Explain Positive Flavoprotein Antibody Tests in Patients without Ophthalamopathy

Hooshang Lahooti, Annamaria De Bellis, Sumihisa Kubota, Kazu Gunji & Jack Wall · Ophthalmology Research: An International Journal · 2016

Background: We have re-visited a possible role of autoantibodies targeting a "64 kDa muscle membrane protein" in the pathogenesis of thyroid-associated ophthalmopathy (TAO). This antigen was identified as the flavoprotein (Fp) subunit of mitochondrial succinate dehydrogenase (SDH...

Open access Research Article 10.9734/OR/2016/27302

Association of the CASQ1 Gene SNP rs3838216 with Graves’ Ophthalmopathy and Hashimoto’s Thyroiditis in Patients with Thyroid Autoimmunity

Hooshang Lahooti, Daniele Cultrone, Senarath Edirimanne, John P. Walsh, Leigh Delbridge, Patrick Cregan, Bernard Champion & Jack R. Wall · Ophthalmology Research: An International Journal · 2014

The pathogenesis of Graves’ ophthalmopathy is poorly understood, but there is evidence for the involvement of calsequestrin (CASQ1) as an autoantigen. Aim: To compare the frequency of the single nucleotide polymorphism (SNP) rs3838216 (located in intron 1 of CASQ1) in patients wi...

Open access Research Article 10.9734/OR/2014/10623

Vitamin D Deficiency may be a Risk Factor for Ophthalmopathy in Patients with Graves’ Hyperthyroidism But Not Hashimoto's Thyroiditis

Hooshang Lahooti, Bryan Wise, H. Tjiang, Bernard Champion & Jack Wall · Ophthalmology Research: An International Journal · 2013

Aims: Apart from its key role in bone metabolism vitamin D plays a role in immune function, cancer prevention and autoimmunity induction. Vitamin D insufficiency (25-50 nmol/L) and deficiency (serum level < 25 nmol/L) are very common in the West Sydney and Blue Mountains areas...

Open access Research Article 10.9734/OR/2014/4795

Calsequestrin is Decreased in the Thyroid Gland of Patients with Graves’ Disease – Further Evidence for a Role of Autoimmunity against this Protein in Graves’ Ophthalmopathy

Daniele Cultrone, Hooshang Lahooti, Senarath Edirimanne, Leigh Delbridge, Bernard Champion & Jack R. Wall · Journal of Advances in Medicine and Medical Research · 2014

Background: The pathogenesis of Graves’ ophthalmopathy (GO) and the mechanism for its link to thyroid autoimmunity is poorly understood. Our present research focuses on the role of the skeletal muscle calcium binding protein calsequestrin (CASQ1). Earlier studies showed that the...

Open access Research Article 10.9734/BJMMR/2014/9504