Hassan A. Osman

Design, Synthesis, Biological Evaluation and Docking Studies of Some New Diclofenac Analogues

Hassan A. Osman & G. M. Nazeruddin · Journal of Pharmaceutical Research International · 2014

Aim: There is still a need for new, selective COX-2 inhibitors with an improved safety profile, therefore, a series of diclofenac analogues were designed and different physicochemical properties were calculated such as log P, hydrogen donor, hydrogen-acceptor, molecular weight an...

Open access Research Article 10.9734/BJPR/2014/5030

Silica Ammonium Acetate as an Efficient and Recyclable Heterogeneous Catalyst for Synthesis of 4H-pyran Derivatives under Ultrasound Irradiation at Ambient Conditions

Abdulkarim M. A. Al-Kadasi, Hassan A. Osman & G. M. Nazeruddin · Chemical Science International Journal · 2014

A simple, versatile and efficient method has been developed for the synthesis of 4H-pyran derivatives 4a-k via a three-component cyclocondensation of aldehydes, malononitrile and ethyl acetoacetate under heterogeneous conditions using silica supported ammonium acetate as the recy...

Open access Research Article 10.9734/ACSJ/2014/5644