Background: Chemotherapy-induced peripheral neuropathy (CIPN), particularly due to paclitaxel, remains a dose-limiting adverse effect. Benfotiamine, a lipid-soluble thiamine precursor, has shown anti-inflammatory, antinociceptive, and neuroprotective effects experimentally. Objec...
Open access
Research Article10.9734/jpri/2026/v38i67851
Background: Paclitaxel-induced painful neuropathy is a major dose-limiting side effect and can persist for up to two years after completing treatment that greatly affects both the course of chemotherapy and quality of life in cancer patients. Peroxisome proliferator-activated rec...
Open access
Research Article10.9734/jpri/2021/v33i38B32112
Background: Bacteria have ability to rapidly evolve, develop strategies to resist antibiotics, and reduce the effectiveness of antibiotics. The emergence and spread of antimicrobial resistance is an important global public health challenge to tackle. Studying antibiotic prescribi...
Open access
Research Article10.9734/jpri/2021/v33i37A31980
Background: Children's unique growth and weakened immune systems make them more vulnerable to infections, particularly upper respiratory tract infections. Notably, inappropriate antibiotic prescribing patterns are mainly due to nonprescription use, overuse and misuse of antibioti...
Open access
Research Article10.9734/jpri/2026/v38i67849
Diabetes mellitus (DM) is one of the most common causes and comorbidities in chronic kidney disease (CKD) globally. Particularly, DM in CKD patients increases the overall risk for kidney failure, atherosclerotic cardiovascular disease, heart failure, and premature mortality. Rece...
Open access
Research Article10.9734/ajrn/2026/v9i1125
Chronic kidney disease (CKD) is one of the leading causes of death. It is characterized by progressive decline in glomerular filtration rate (GFR), irreversible structural and functional kidney damage often associated with co-morbidities and multiple complications, including hype...
Open access
Research Article10.9734/ijanr/2026/v9i197
Insomnia is when a person feels difficulty falling asleep or staying asleep, often associated with complications, such as fatigue, sleepiness, etc. Insomnia may cause disruptions in daytime physical and mental abilities. Orexins or hypocretins are the neuropeptides secreted from...
Open access
Research Article10.9734/indj/2024/v21i6457
Background: Neuropathic pain is a chronic incapacitating painful condition for which there is no effective treatment. The peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear transcription factors that play key roles in modulating immune and inflammato...
Open access
Research Article10.9734/jpri/2021/v33i39B32176