Nimesulide Inhibits MAPK/COX-2 Pathway, and Prevents Oxidative Stress, Inflammation, and Apoptosis in Testes of Cisplatin-Challenged Rats
Amr A. Fouad, Hanaa M. Khalaf, Usama I. Akl & Manal I. Abdelghany · Journal of Pharmaceutical Research International · 2020
The potential testicular protective effect of nimesulide (NSE) was studied in cisplatin (CSP)-challenged rats. NSE therapy (10 mg/kg/day, p.o.) was applied for 15 days, and a single dose of CSP (7 mg/kg, i.p.) was administered on the 10th day. CSP significantly decreased the leve...
Open access
Research Article
10.9734/jpri/2020/v32i2230769