Goodnews Onyedikachi Ikeh

Thermodynamic and Kinetic Elucidation of the Biogenic Capping Mechanism: Evidence of Ordered Self-assembly in Gongronema latifolium-Silver Nanoparticles

Goodnews Onyedikachi Ikeh, Hannah Ndidiamaka Okorie, Ibeabuchi J. Ali, Jasmine Kayanian, Rita C. Okpoto, Charles C. Diovu & Sunday Kaura · Physical Science International Journal · 2026

While our previous research successfully established the exceptional in vivo safety profile (LD50 > 5000 mg/kg) and the potent antimalarial efficacy of silver nanoparticles synthesized using Gongronema latifolium, and subsequently identified both Sarsasapogenin and Cinchonidin...

Open access Research Article 10.9734/psij/2026/v30i2938

Translational Insight into Gongronema latifolium-silver Nanoparticles: Linking in vivo Safety to Molecular Antimalarial Mechanism

Goodnews Onyedikachi Ikeh, Jasmine Kayanian, Nkoyo Imelda Nubila, Charles C. Diovu, Sunday Kaura, Ndidiamaka H. Okorie & Ibeabuchi J. Ali · Journal of Advances in Medical and Pharmaceutical Sciences · 2026

Building upon our recent finding that the biopolymer matrix of green-synthesized silver nanoparticles (AgNPs) dictates their exceptional safety (LD50 > 5000 mg/kg) and antimalarial efficacy, this study employed a computational framework to de-convolute the molecular identity o...

Open access Research Article 10.9734/jamps/2026/v28i3850

Molecular Spectroscopic (FTIR and UV-Vis) and Hyphenated Chromatographic (GC–MS) Characterization of Bioactive Compounds Present in Different Solvent Fractions of Extract of Leaf of Cola hispida Brenan & Keay Sterculiaceae

Goodnews Onyedikachi Ikeh, Njideka Ifeoma Ani, Vincent Uchechukwu Ude, Jude Kosisochukwu Onyia, Charles C. Diovu & Rita Chiamaka Okpoto · South Asian Research Journal of Natural Products · 2025

Cola hispida Brenan & Keay (Sterculiaceae), a tropical plant native to West and Central Africa, is widely used in traditional medicine for its therapeutic properties, yet its phytochemical composition remains underexplored. This study investigates the bioactive compounds in d...

Open access Research Article 10.9734/sarjnp/2025/v8i2194

Biogenic Synthesis and Comparative Assessment of the Antimicrobial Activities of Silver and Zinc Nanoparticles of Dialium guineense Leaf Extract against Human Pathogens

Goodnews Onyedikachi Ikeh, Ugwu PE, Rita Chiamaka Okpoto, Njoku EA, Charles C. Diovu & Adonu CC · Journal of Complementary and Alternative Medical Research · 2024

Aim: The study aimed to perform a comparative evaluation of the antimicrobial activities of green synthesis of silver and zinc nanoparticles. Study Design: Experimental. Methodology: A biogenic and facile method of synthesis of silver and zinc oxide nanoparticles (DGL—SNPs and DG...

Open access Research Article 10.9734/jocamr/2024/v25i12607

Oral Biopharmaceutics and In vitro Pharmacokinetics of Commercially Available Pharmaceutical Formulations of Paracetamol: Implications in Paediatric Medicine

Goodnews Onyedikachi Ikeh, Nwafor MN, Ndubuisi MN & Okolo KO · Journal of Complementary and Alternative Medical Research · 2024

Aim: This study aimed to compare the oral pharmacokinetics of different paediatric paracetamol dosage forms that are commercially available in Nigeria. Study Design: Experimental. Place and Duration of Study: Faculty of Pharmaceutical Sciences, Enugu State University of Science a...

Open access Research Article 10.9734/jocamr/2024/v25i12603

Precursor Chemistry and Antimicrobial Performance: A Green Synthesis Approach to the Zinc Oxide Nanoparticles

Ndidiamaka Hannah Okorie, Goodnews Onyedikachi Ikeh, Cyril Chekwube Adonu, Chigozie Peace Okorie, Romanus Chijioke Omeh & Anthony Kelechi Nwangwu · Asian Journal of Applied Chemistry Research · 2025

The increasing emphasis on sustainable nanotechnology has propelled the development of green synthesis methodologies for nanoparticle production. This study investigates the impact of precursor chemistry on the nucleation and growth of zinc oxide nanoparticles (ZnO NPs) synthesiz...

Open access Research Article 10.9734/ajacr/2025/v16i2333

Phytochemical-Mediated ZnO Nanoparticles from Chromolaena odorata: Structural Characterisation and Antimicrobial Efficacy against Multidrug-Resistant Clinical Isolates, Nigeria

Hannah Ndidiamaka Okorie, Chigozie Peace Okorie, Goodnews Onyedikachi Ikeh, Angel Chihurumnanya Leonard, Nwoke Obinna Chidubem, Igwe Chidiebere Collins & Anthony A. Attama · Journal of Pharmaceutical Research International · 2025

Nanoparticles (NPs), ranging from 1–100 nm, exhibit unique properties due to their compact atomic arrangement, enhancing mechanical, electrical, magnetic, optical, catalytic, and antibacterial characteristics compared to macroscopic materials. The rising threat of multidrug-resis...

Open access Research Article 10.9734/jpri/2025/v37i107755

Research on Plant-based Management of Haemorrhoids: Evidence from Extracts of Mimosa pudica L

Chigozie Peace Okorie, Hannah N. Okorie, Goodnews Onyedikachi Ikeh, Kennedy Oluigbo, Goldy Iruoma Ani, Nwoke Obinna Chidubem & Nwoke Nwabunwanne Chukwudi · Journal of Pharmaceutical Research International · 2025

Haemorrhoids, characterised by inflamed and swollen anorectal veins, represent a significant global health burden, with profound impacts in regions with limited healthcare access, such as Nigeria and sub-Saharan Africa. Globally, the prevalence of haemorrhoids is estimated at 4.4...

Open access Research Article 10.9734/jpri/2025/v37i107751

In vivo Pharmacological Evaluation of the Anti-inflammatory and Analgesic Effects of Cola hispida Methanol Leaf Extract and Its Fractions

Njideka Ifeoma Ani, Nkoyo Imelda Nubila, Goodnews Onyedikachi Ikeh, Jude Kosisochukwu Onyia, Vincent Uchechukwu Ude & Charles Chinedu Diovu · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2025

Cola hispida  Brenan & Keay (Sterculiaceae), a West African plant used in Nigerian Ethnomedicine for pain and inflammation, was evaluated for its anti-inflammatory and analgesic properties in Wistar rats. The methanol leaf extract (CHME) and its n-hexane (CHHF), ethyl acetate...

Open access Research Article 10.9734/ajrimps/2025/v14i4347

Evaluation of the Anti Ulcer Effect of Extract of Chromolaena odorata Leaves on Ethanol and Indomethacin Induced Ulcer Models

Hannah Ndidiamaka Okorie, Peace Chiagozie Okorie, Linda Nkechinyere Umegbo, Nnenna Ajagu, Arinze Ndibe, Kennedy E. Oluigbo & Goodnews Onyedikachi Ikeh · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2026

Public health is greatly impacted by peptic ulcer disease, a chronic illness marked by sores in the lower oesophagus, duodenum, or stomach. In ethnomedicine, Chromolaena odorata has long been used to treat ulcers. The study evaluated the anti-ulcer properties of the methanol extr...

Open access Research Article 10.9734/ajrimps/2026/v15i3397