Germeen N. S. Girgis

Formulation and Evaluation of Pluronic F127 Thermosetting Gels Containing Atorvastatin Calcium as Novel Ophthalmic Delivery Systems

Germeen N. S. Girgis · Ophthalmology Research: An International Journal · 2018

Aims: This study aims to formulate and evaluate ophthalmic thermo-sensitive gels containing atorvastatin calcium. The major problem of the drug is poor water solubility, and hence the ocular bioavailability, complexation with cyclodextrin is an attempt to solve this problem. The...

Open access Research Article 10.9734/OR/2018/44459

Surface-Decorated Nanocarrier as a Targeted Drug Delivery Cargo to Folate Receptor-Overexpressing Cells for Enhancing Anti-cancer and Anti-inflammatory Activity

Yomna Adel Gabr, Germeen N. S. Girgis & Hassan Mohamed EL-Sabbagh · Journal of Pharmaceutical Research International · 2023

Aims: Folate receptor (FR) is overexpressed in most cancer cells and activated macrophages entailed in rheumatoid arthritis (RA). The aim of the current study was the fabrication of FR-targeted nanocarrier loaded with methotrexate (MTX) to magnify its therapeutic efficacy and lim...

Open access Research Article 10.9734/jpri/2023/v35i187393

A Promising Ternary Solid Dispersion of Aceclofenac Containing Tablet with Enhanced Dissolution, and Potentiated Anti-inflammatory Efficacy

Amira Samir Ebraheem, Abd El-Gawad Helmy Abd El-Gawad & Germeen N. S. Girgis · Journal of Pharmaceutical Research International · 2022

The major objective of the current study is to implement a plan to enhance the dissolution rate and oral bioavailability of a poorly water-soluble aceclofenac. The drug is classified according to the biopharmaceutical classification system as class II drug. Amorphous alkalinized...

Open access Research Article 10.9734/jpri/2022/v34i647290